Long-Term Safety and Effectiveness of Thyrotropin Alfa in Japanese Patients: A Post-Marketing Surveillance Study.

INTRODUCTION: Real-world evidence of the safety and effectiveness of recombinant human thyroid-stimulating hormone (rhTSH; thyrotropin alfa) in Japanese patients is lacking.
METHODS: This was a post-marketing surveillance study that included all Japanese patients who received thyrotropin alfa, either as a supporting diagnostic from January 2009 to December 2016, or as adjunctive treatment for ablation from May 2012 to October 2018. Information was collected on patient demographics, thyroid cancer characteristics, adverse drug reactions (ADRs), scintigraphy, serum thyroglobulin (Tg) testing, and hypothyroidism symptoms.
RESULTS: A total of 9268 patients were included in the safety analysis and 9031 in the effectiveness analysis. In the safety analysis set, 3444 patients received thyrotropin alfa as a diagnostic and 5822 received it as treatment. ADRs occurred in 7.1% (n = 660) of patients, including 9.4% (n = 324) of patients who received thyrotropin alfa as a diagnostic and 5.8% (n = 336) of patients who received it as treatment. Nausea was the most common ADR (4.0% of overall safety population). Among patients who received thyrotropin alfa as a diagnostic (n = 1835), the Tg test was positive in 53.6% after the second dose. The scintigram was rated as "readable" in 3023 of the 3054 patients included in this analysis (99.0%). Of the 765 patients who were included in the assessment of response to ablation at 6 months to 1 year after the procedure, 621 (81.2%) were considered to have had "treatment success". There were no significant differences in the proportions of patients who had hypothyroidism symptoms before the first and after the second dose of thyrotropin alfa.
CONCLUSION: In this large post-marketing surveillance study, thyrotropin alfa was well tolerated and showed effectiveness that was comparable to that observed in randomised, controlled trials.

Key Summary Points

Introduction

Thyroid cancer is relatively rare, with approximately 3700 and 52,890 new cases occurring each year in the UK and the USA, respectively [1, 2]. In Japan, the estimated number of thyroid cancer cases was 15,629 (4233 men and 11,396 women) in 2013 [3]. The crude mortality rate per 100,000 individuals was 0.96 for men and 1.86 for women [3].

Radioactive iodine (RAI) is used in both the diagnosis and treatment of thyroid cancer [4]. Adjunct RAI therapy is recommended for intermediate- and high-risk patients according to the American Thyroid Association (ATA) stratification system following surgery [4]. In patients with differentiated thyroid cancer, residual or metastatic thyroid tissue should be monitored every 0.5–1 year, which requires a thyroglobulin (Tg) test. To perform this test accurately, patients should have no circulating thyroid hormone in order to elicit an increase in endogenous thyroid-stimulating hormone (TSH). ATA guidelines recommend that the TSH level should increase to at least 30 mIU/L before RAI therapy or diagnostic testing [4]. Two methods are available for thyroid ablation prior to Tg testing: withdrawing the patient’s thyroxine therapy or administering an agent to block endogenous TSH release.

Thyrotropin alfa (Thyrogen®, Genzyme, USA) is a recombinant human TSH that is approved in the EU, the USA and Japan for use with serum Tg testing with or without RAI imaging for the detection of thyroid remnants and well-differentiated thyroid cancer in post-thyroidectomy patients, as well as for use in combination with RAI for ablation of thyroid tissue remnants in patients who have undergone a near-total or total thyroidectomy for well-differentiated thyroid cancer and who do not have evidence of metastatic disease [5, 6]. Thyrotropin alfa is administered as an intramuscular injection and has been used in more than 45 countries. ATA guidelines recommend using thyrotropin alfa as an alternative to thyroxine withdrawal for remnant ablation or adjuvant therapy in patients who have undergone near-total or total thyroidectomy [4].

While a number of large, multicentre clinical trials (such as HiLo [7] and ESTIMABL [8]) have demonstrated the effectiveness and safety of thyrotropin alfa for the management of thyroid cancer, real-world evidence is lacking. In addition, a total of only ten patients with differentiated thyroid cancer took part in a clinical trial of thyrotropin alfa conducted in Japan [9]. To address this knowledge gap, a post-marketing surveillance study of thyrotropin alfa in Japanese patients was conducted, the results of which are reported here.

Methods

Study Design and Patients

This was a post-marketing surveillance study conducted to investigate the safety and effectiveness of thyrotropin alfa in Japan. There are two approved indications for thyrotropin alfa in Japan: (1) to support diagnosis, in combination with RAI scintigraphy and serum Tg test, or Tg test alone for patients who had a near-total or total thyroidectomy for differentiated thyroid cancer; and (2) as an adjunctive treatment for RAI ablation of thyroid tissue remnants in patients who have had a near-total or total thyroidectomy for well-differentiated thyroid cancer and who have no evidence of metastatic thyroid cancer.

The total study period was from January 2009 to December 2016 for indication 1 and from May 2012 to October 2018 for indication 2. All patients who received thyrotropin alfa for indication 1 or 2 during the respective timeframes were registered in this study using an internet-based central registration system.

The study was conducted in accordance with the relevant Japanese regulations [Ministerial Ordinance on Good Post-Marketing Study Practice (GPSP), Ministry of Health, Labour and Welfare Ordinance Number 171, December 20, 2004]. The study protocol was reviewed and approved by the Japanese regulatory authority prior to study initiation. The study underwent review by the ethics committees of the participating medical institutions. Informed consent was not acquired during this study, because GPSP does not require informed consent acquisition for post-marketing surveillance studies. However, only sites which agreed to the publication of the study findings were included.

Data Collection

Each physician submitted case report forms (CRFs) to the registration system approximately 1 month after the end of the 2-week observation period following Tg testing, scintigraphy or ablation. If thyrotropin alfa was administered as adjunctive treatment for ablation, follow-up was conducted using follow-up CRFs for the assessment of response ablation for up to 3 years.

The following information was collected: patient demographics [age, sex, pregnancy, breastfeeding, height, body weight, inpatient/outpatient status, treatment experience with thyrotropin alfa (number of diagnostic tests), medical history, history of allergy, and presence of complications (including renal and hepatic impairment)]; characteristics of differentiated thyroid cancer [histological classification, time of occurrence, history of surgery (thyroidectomy), history of thyroid remnant ablation with RAI, and indication for the use of thyrotropin alfa]; details of thyrotropin alfa administration, including the number of doses; concomitant treatments; adverse drug reactions (ADRs); restriction of dietary iodine intake if scintigraphy was performed; anti-TSH antibody status (in potentially antibody-positive patients as determined by the treating physician); results of Tg testing and scintigraphy; and symptoms of hypothyroidism.

Outcomes and Measures

Patients who received at least one dose of thyrotropin alfa were included in the safety analysis set. Patients who were included in this set and did not meet any of the following criteria were included in the effectiveness analysis set: did not receive two doses of thyrotropin alfa every 24 h, had a history of surgery for thyroid cancer other than total or near-total thyroidectomy, had thyroid cancer other than differentiated thyroid carcinoma, did not undergo Tg testing or scintigraphy (for patients who received thyrotropin alfa as a diagnostic), were not treated with radio-iodine (for patients who received thyrotropin alfa for ablation assistance), or received thyrotropin alfa for an off-label indication.

The main outcome of the study was the proportion of patients in the safety analysis set who had ADRs. Adverse events (AEs) were defined as unintended, harmful events that were considered as such by the attending physician or the sponsor. ADRs are defined as adverse events other than “no relation to study drug”, which were evaluated by the attending physician or the sponsor. ADRs were classified according to the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Medical Dictionary for Regulatory Activities, Japanese edition, v.21.0. Information on serious AEs, which were determined serious either by the physician or the sponsor, was also collected.

The effectiveness of thyrotropin alfa as a diagnostic was assessed in patients who were included in the effectiveness analysis set, had a Tg test, history of residual thyroid destruction due to RAI, and did not express anti-Tg antibodies. This study was designed based on the USA guidelines [10]. Tg testing results were classified into four categories: Tg ≤ 2 ng/mL, Tg > 2 to < 5 ng/mL, Tg ≥ 5 to < 10 ng/mL, and Tg ≥ 10 ng/mL, where ≤ 2 ng/mL was defined as “negative” and > 2 ng/mL was defined as “positive”.

The results of scintigraphy were evaluated for resolution and quality of visualisation in patients who were included in the effectiveness analysis set and had a scintigram. Resolution was classified as “readable” or “not readable” by the reporting physician. Quality of visualisation of the thyroid bed, neck other than thyroid bed (cervical lymph node metastasis), mediastinal metastasis, lung metastasis or other distant metastasis sites was assessed and classified as “visualised”, “not visualised” or “indeterminate” by the reporting physician.

Sixteen symptoms of hypothyroidism were evaluated before the first and after the second dose of thyrotropin alfa by the treating physician who selected "no", "suspected" or "yes" for each symptom in the CRF. For the purposes of this analysis, any symptoms marked as "suspected" or "yes" were considered to be present, whereas only symptoms marked as “no” were considered to be absent.

In addition, response to ablation was evaluated at 6 months to 1 year after ablation. Ablation was evaluated based on response criteria of "no visualisation of thyroid bed" or "RAI uptake of 0.1% or less" using results rated by the reporting physician as either "success", "inadequate response", "without success" or "unevaluable".

Statistical Analysis

The incidence of ADRs was compared among subgroups by patient characteristics. Comparisons between subgroups were made using Fisher's exact test or chi-squared test with a significance level of 0.05.

Results

Patient disposition and characteristics

By the end of study period (October 15, 2018), 12,756 patients’ data had been collected. Of these, 9283 patients from the 101 hospitals/clinics that agreed to the publication of data, including 3451 patients who received thyrotropin alfa for diagnostic purposes and 5830 patients who received it therapeutically. In addition, one patient received thyrotropin alfa for lymph node metastasis and one patient for Graves’ disease. Of these, 9268 patients were included in the safety analysis set and 9031 were included in the effectiveness analysis set (Fig. 1). The characteristics of patients at baseline are summarised in Tables 1 and 2.

Fig. 1

Disposition of patients

Table 1

Baseline characteristics of patients

	Total (n = 9268)	Supporting diagnostic ( n = 3444)	Adjunctive treatment for ablation (n = 5822)	Other (n = 2)
Female sex, n (%)	6447 (69.6)	2472 (71.8)	3974 (68.3)	1 (50.0)
Age, years
Mean (SD)	56.0 (15.0)	57.0 (14.6)	55.5 (15.2)	58.5 (24.8)
< 15	12 (0.1)	3.0 (0.1)	9 (0.2)	–
≥ 15 – < 65	6021 (65.0)	2192 (63.6)	3828 (65.8)	1 (50.0)
≥ 65	3235 (34.9)	1249 (36.3)	1985 (34.1)	1 (50.0)
Unknown/unstated	–	–	–	–
Body weight, kg
n	8792	3235	5556	1
Mean (SD)	60.2 (13.1)	59.7 (12.6)	60.4 (13.3)	61.3 (–)
Body mass index, kg/m2
n	8720	3197	5522	1
Mean (SD)	23.4 (4.1)	23.4 (4.0)	23.5 (4.2)	27.6 (–)
Inpatient/outpatient at registration
Outpatient	6535 (70.5)	2908 (84.4)	3626 (62.3)	1 (50.0)
Inpatient	2713 (29.3)	532 (15.4)	2180 (37.4)	1 (50.0)
Unknown/unstated	20 (0.2)	4 (0.1)	16 (0.3)	–
Comorbiditiesa
No	4518 (48.7)	1882 (54.6)	2636 (45.3)	–
Yes	4741 (51.2)	1562 (45.4)	3177 (54.6)	2 (100.0)
Unknown/unstated	9 (0.1)	–	9 (0.2)	–
Dose of radioactive iodine (mCi) as supporting diagnostic
n	2266	2266	–	–
Median (min, max)	8.4 (0.3, 131.0)	8.4 (0.3, 131.0)	–	–
Dose of radioactive iodine (mCi) as adjunctive treatment for ablation
n	5776	–	5776	–
Median (min, max)	30 (3, 300)	–	30 (3, 300)	–
Dose of thyrotropin alfa
n	9268	3444	5822	2
Median (min, max)	2 (1, 2)	2 (1, 2)	2 (1, 2)	2 (2, 2)

SD standard deviation

aComorbidities were all coexisting disorders, including kidney dysfunction, liver dysfunction, and others

Table 2

Patient characteristics related to thyroid cancer

	Total (n = 9268)	Supporting diagnostic (n = 3444)	Adjunctive treatment for ablation (n = 5822)	Other (n = 2)
Histologic classification of differentiated thyroid cancer
Papillary carcinoma	8504 (91.8)	3145 (91.3)	5357 (92.0)	2 (100.0)
Follicular carcinoma	694 (7.5)	277 (8.0)	417 (7.2)	0 (0)
Other	164 (1.8)	65 (1.9)	99 (1.7)	0 (0)
Unknown/unstated	4 (0.0)	0 (0)	4 (0.1)	0 (0)
Duration of illness, years
< 5	3071 (33.1)	991 (28.8)	2080 (35.7)	0 (0)
≥ 5 – < 10	418 (4.5)	210 (6.1)	207 (3.6)	1 (50.0)
≥ 10	410 (4.4)	237 (6.9)	173 (3.0)	0 (0)
Unknown	5369 (57.9)	2006 (58.2)	3362 (57.7)	1 (50.0)
Number of previous surgeries
1	7838 (84.6)	2878 (83.6)	4960 (85.2)	0 (0)
2	1327 (14.3)	513 (14.9)	814 (14.0)	0 (0)
3	71 (0.8)	38 (1.1)	33 (0.6)	0 (0)
≥ 4	26 (0.3)	14 (0.4)	11 (0.2)	1 (50.0)
Unknown/unstated	6 (0.1)	1 (0.0)	4 (0.1)	1 (50.0)
Previous thyroid surgery
Total thyroidectomy	9020 (97.3)	3267 (94.9)	5752 (98.8)	1 (50.0)
Near-total thyroidectomy	184 (2.0)	131 (3.8)	53 (0.9)	0 (0)
Subtotal thyroidectomy	17 (0.2)	13 (0.4)	4 (0.1)	0 (0)
Partial thyroidectomy	2 (0.0)	2 (0.1)	0 (0)	0 (0)
Hemithyroidectomy	36 (0.4)	28 (0.8)	8 (0.1)	0 (0)
Unknown/unstated	9 (0.1)	3 (0.1)	5 (0.1)	1 (50.0)
Previous ablations, times
None	5454 (58.8)	684 (19.9)	4769 (81.9)	1 (50.0)
Any	3783 (40.8)	2741 (79.6)	1041 (17.9)	1 (50.0)
1	3231 (34.9)	2402 (69.7)	828 (14.2)	1 (50.0)
2	369 (4.0)	212 (6.2)	157 (2.7)	0 (0)
3	94 (1.0)	63 (1.8)	31 (0.5)	0 (0)
≥ 4	89 (1.0)	64 (1.9)	25 (0.4)	0 (0)
Unknown/unstated	31 (0.3)	19 (0.6)	12 (0.2)	0 (0)
Total radioiodine dose, mCi
< 10	37 (0.4)	36 (1.0)	1 (0.0)	0 (0)
≥ 10 – < 30	112 (1.2)	101 (2.9)	11 (0.2)	0 (0)
≥ 30 – < 50	2046 (22.1)	1462 (42.5)	584 (10.0)	0 (0)
≥ 50 – < 100	680 (7.3)	532 (15.4)	148 (2.5)	0 (0)
≥ 100	908 (9.8)	610 (17.7)	297 (5.1)	1 (50.0)
Time from onset to date of total thyroidectomy, years
< 5	3287 (35.5)	1132 (32.9)	2154 (37.0)	1 (50.0)
≥ 5 – < 10	205 (2.2)	76 (2.2)	129 (2.2)	0 (0)
≥ 10	176 (1.9)	79 (2.3)	97 (1.7)	0 (0)
Unknown	5352 (57.7)	1980 (57.5)	3372 (57.9)	0 (0)

Data are n (%)

Safety

A total of 853 individual ADRs were recorded in 660 patients (7.1%) in the safety analysis set. ADRs occurred in 9.4% (n = 324) of patients who received thyrotropin alfa as a diagnostic and 5.8% (n = 336) of patients who received it as treatment. The most common ADR was nausea (4.0% of patients in the total safety population, 5.4% of patients in the diagnostic group and 3.2% of patients in the treatment group). The second and third most common ADRs were vomiting (0.7% of patients in the total safety population, 0.8% of patients in the diagnostic group and 0.6% of patients in the treatment group) and headache (0.6%, 0.7% and 0.6%, respectively).

Thirty-eight serious AEs were reported in 25 patients (Table 3); 33 of these events had resolved or were in remission at the time of analysis, 3 were not resolved and the outcomes of 2 were unknown. Of the serious AEs, 16 events (n = 11) were considered to be related to thyrotropin alfa (SADRs). Fourteen SADR events were resolved or in remission, including one patient who received thyrotropin alfa as a diagnostic and was hospitalised for acute myocardial infarction. This patient was in remission at the time of analysis. One patient with nephrotic syndrome had been on treatment at the time of data cut-off and the outcome of a patient with back pain was not known.

Table 3

Number of patients who had a serious adverse event during the study

Preferred term	Total (n = 9268)	Supporting diagnostic (n = 3444)	Adjunctive treatment for ablation (n = 5822)
Vomiting	4	–	4
Nausea	2	–	2
Loss of consciousness	1	1	–
Back pain	1	1	–
Atrial fibrillation	1	–	1
Pleural effusion	1	–	1
Acute myocardial infarction	1	1	–
Dizziness	1	–	1
Laryngeal oedema	1	–	1
Cancer pain	1	1	–
Nephrotic syndrome	1	–	1
Hyponatraemia	1	–	1

Effectiveness

A total of 1835 patients were eligible for the analysis of the effectiveness of thyrotropin alfa to support diagnostic Tg testing. The Tg value was ≤ 2 ng/mL in 851 patients, > 2 to < 5 ng/mL in 222 patients, ≥ 5 to < 10 ng/mL in 166 patients, and ≥ 10 ng/mL in 596 patients. After the second dose of thyrotropin alfa, the Tg test was positive in 53.6% of patients who used this drug as a diagnostic (n = 1835). Median (range) Tg was 0.50 (0.00–5677.00) ng/mL before the first dose and 2.30 (0.04–29,496.00) ng/mL after the second dose.

The scintigram was rated as “readable” in 3023 of the 3054 patients included in this analysis (99.0%). The detection rate was 20.0% for the thyroid gland bed and 25.4% for any part of the body. Twenty patients who received thyrotropin alfa as a diagnostic had an additional Tg test using thyroid hormone withdrawal.

Of the 765 patients who were included in the assessment of response to RAI treatment at 6 months to 1 year after the procedure, 621 (81.2%) were considered to have had “treatment success”. Scintigraphy of the thyroid bed was performed in 764 of the 765 patients and visualisation was achieved 62 patients, while no visualisation was achieved in 606 (79.3%) patients. Of the patients who received thyrotropin alfa as treatment, 26 patients had additional scintigraphy or Tg testing with thyroid hormone withdrawal.

The proportion of patients who had any of the 16 hypothyroid symptoms after the second dose of thyrotropin alfa was not significantly different to the proportion before the first dose of thyrotropin alfa (Table 4), and this was the case in patients receiving thyrotropin alfa for diagnostic or therapeutic indications.

Table 4

Incidence of the signs or symptoms of hypothyroidism before the first and after the second dose of thyrotropin alfa

Sign/symptom	Number of patients evaluated	Number of patients affected, n (%)
		Before first dose	After second dose
Reduced sweating	6902	17 (0.25)	18 (0.26)
Dry skin	6904	81 (1.17)	72 (1.04)
Coldness	6905	93 (1.35)	87 (1.26)
Weight gain	6904	60 (0.87)	49 (0.71)
Constipation	6908	109 (1.58)	104 (1.51)
Hoarseness	6898	254 (3.68)	236 (3.42)
Dysesthesia	6906	33 (0.48)	47 (0.68)
Hearing loss	6907	47 (0.68)	43 (0.62)
Slow movement	6905	20 (0.29)	25 (0.36)
Rough skin	6906	39 (0.56)	40 (0.58)
Skin coldness	6906	32 (0.46)	34 (0.49)
Oedema of the eyelids	6905	19 (0.28)	20 (0.29)
Slow Achilles tendon reflex	6877	32 (0.47)	15 (0.22)
Decreased pulse rate	6905	3 (0.04)	6 (0.09)
Oedema	6903	64 (0.93)	48 (0.70)
Leg cramps	6875	158 (2.30)	119 (1.73)

Discussion

To our knowledge, this is the largest study to date evaluating the safety and effectiveness of thyrotropin alfa in patients with thyroid cancer in Japan. These results are consistent with prior studies showing that thyrotropin alfa has an acceptable safety profile and is generally well tolerated [7, 8, 11].

After 1 year of treatment, the response rate was 81%. This finding is comparable with those of a study which compared low-dose RAI plus thyrotropin alfa with high-dose RAI plus thyroid hormone withdrawal, in which the 6- to 9-month response rates were 84.3% and 87.6%, respectively [7]. The rates of recurrence at 3 years were 1.5% in patients who received thyrotropin alfa and 2.1% in those who underwent thyroid hormone withdrawal [12]. The high response rate of thyrotropin alfa in our study is encouraging, since the data were collected under real-world conditions and, therefore, are more generalisable to a typical clinical practice population than data from randomised controlled trials in highly selected patient populations [13].

Using thyrotropin alfa for thyroid ablation before RAI administration is becoming the standard of care in many countries in preference to thyroid hormone withdrawal [14, 15]. This is based on data showing diagnostic and therapeutic equivalence between the two thyroid ablation techniques, but thyrotropin alfa is associated with fewer adverse events and no deterioration in quality of life caused by hypothyroid symptoms [16]. In the present study, the incidence of hypothyroid symptoms before thyrotropin alfa administration was low, and there were no significant differences in the proportion of patients who had any of the 16 symptoms before the first and after the second dose of thyrotropin alfa, whether in patients who received it as a supporting diagnostic or as adjunctive treatment for ablation, supporting the lack of impact of thyrotropin alfa on these signs/symptoms. The ability to continue levothyroxine treatment during thyroid ablation is an important advantage of thyrotropin alfa [14]. Patients who undergo thyroid hormone withdrawal experience significantly more symptoms of hypothyroidism, including dysphoric mood, compared with patients who receive thyrotropin alfa as the RAI stimulant [11], and this is associated with a significant (albeit transient) deterioration in quality of life [16].

As thyrotropin alfa can be used as an alternative for thyroid hormone withdrawal, it is important to evaluate whether an additional scintigram or Tg testing with thyroid hormone withdrawal was needed after using thyrotropin alfa for either diagnosis or treatment. In our study, very few patients (1.5% in the treatment group and 1.1% in the diagnosis group) had additional testing with hormone withdrawal. However, our study was not designed to collect detailed information on the reason for additional testing, so no clear conclusions can be drawn from the rates of additional testing.

This study included a large population of more than 9000 patients with thyroid cancer. The mean age of the patients was 56 years; however, 65% were less than 65 years old. The majority of patients (91.8%) had papillary carcinoma and 84.6% had undergone one surgery, which in most cases (97.3%) was total thyroidectomy. The duration of illness was less than 5 years in 33.1% of included patients; however, it was unknown in 57.9%, as the date of first diagnosis was not recorded in this study. These data suggest that thyrotropin alfa is being used for patients with low- and intermediate-risk differentiated thyroid cancer, in accordance with guidelines [4].

This study had a number of limitations. Firstly, only Japanese patients were included and, therefore, the results may not be generalisable to other populations. Secondly, the overall duration of the study was long and guideline recommendations and treatment and diagnostic options changed during this period, which could have resulted in inconsistency in clinical practice.

Conclusions

This was the largest study to date to evaluate the safety and effectiveness of thyrotropin alfa in Japanese patients with thyroid cancer. The results show that thyrotropin alfa was generally well tolerated and had an acceptable safety profile. The real-world effectiveness of thyrotropin alfa in the present study was comparable to that observed in previous randomised controlled trials. The use of thyrotropin alfa was not associated with a deterioration in the symptoms of hypothyroidism.

Why carry out this study?

There is a lack of real-world data on the clinical effectiveness and safety of thyrotropin alfa (recombinant human thyroid-stimulating hormone) in Japanese patients

This study was conducted to investigate the clinical effectiveness and safety of thyrotropin alfa, either as a diagnostic or therapeutic agent, in a real-world population of Japanese patients (n > 9000) between May 2012 and October 2018

What was learned from this study?

Thyrotropin alfa was generally well tolerated, with adverse drug reactions being reported in 9.4% and 5.8% of patients who received it for diagnostic and therapeutic (ablation) purposes, respectively

Over 80% of patients who received thyrotropin alfa for ablation were considered to have a successful treatment outcome 6–12 months post-procedure

In real-world use in Japan, thyrotropin alfa appears to have clinical effects comparable to those achieved in randomised controlled trials in the Japanese population