Ruiqi Pang1, Shuo Feng2, Kai Cao1, Yunxiao Sun1, Yiqin Guo1, Dandan Ma1, Chi Pui Pang3, Xiangyi Liu4, Jingyu Qian4, Yuan Xie1, Yan Shi1, Hailong He1, Jun Peng5, Congyan Chen5, Jing Cui6, Siloka A Labisi1, Yue Zhang1, Yingdi Fu1, Jiaying Li1, Yue Wan1, Chen Xin1, Hanruo Liu1, Qing Zhang1, Robert N Weinreb7, Huaizhou Wang1, Ningli Wang8. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 2. Departments of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 3. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. 4. Departments of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 5. Hangzhou Biozon Medical Lab Co Ltd, Hangzhou, China. 6. Physical Examination Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 7. Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA. 8. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. wningli@vip.163.com.
Abstract
OBJECTIVES: To evaluate the association between serum retinol concentration and normal-tension glaucoma (NTG). METHODS: A total of 345 study subjects were recruited in a prospective cross-sectional study: 101 patients with NTG, 106 patients with high-pressure primary open-angle glaucoma (POAG) and 138 healthy control subjects. Serum retinol concentration in fasting blood samples was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). All study subjects were given complete ophthalmic examinations and diagnosed by two glaucoma sub-specialists. RESULTS: Serum retinol concentrations in NTG, POAG, and controls were 338.90 ± 103.23 ng/mL, 405.22 ± 114.12 ng/mL, and 408.84 ± 122.36 ng/mL respectively. NTG patients had lower serum retinol concentrations than POAG (p < 0.001) or healthy controls (p < 0.001). There was no statistical difference between the POAG and healthy controls (p = 0.780). Higher proportion of NTG patients (37.6%) than POAG (17.9%) or controls (21.7%) had serum retinol concentrations lower than 300 ng/mL. Serum retinol was positively correlated with optic nerve sheath diameter (ONSD) (r = 0.349, p = 0.001) in glaucoma patients and not associated with any other demographic features or ophthalmic biometric parameters in the NTG patients. Multivariate logistic regression showed that serum retinol (OR = 0.898, 95CI%: 0.851-0.947) was associated with incident NTG. CONCLUSIONS: NTG patients had lower serum retinol concentrations. Serum retinol uniquely associated with NTG makes it a new potential option for the diagnosis and treatment of the disease.
OBJECTIVES: To evaluate the association between serum retinol concentration and normal-tension glaucoma (NTG). METHODS: A total of 345 study subjects were recruited in a prospective cross-sectional study: 101 patients with NTG, 106 patients with high-pressure primary open-angle glaucoma (POAG) and 138 healthy control subjects. Serum retinol concentration in fasting blood samples was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). All study subjects were given complete ophthalmic examinations and diagnosed by two glaucoma sub-specialists. RESULTS: Serum retinol concentrations in NTG, POAG, and controls were 338.90 ± 103.23 ng/mL, 405.22 ± 114.12 ng/mL, and 408.84 ± 122.36 ng/mL respectively. NTG patients had lower serum retinol concentrations than POAG (p < 0.001) or healthy controls (p < 0.001). There was no statistical difference between the POAG and healthy controls (p = 0.780). Higher proportion of NTG patients (37.6%) than POAG (17.9%) or controls (21.7%) had serum retinol concentrations lower than 300 ng/mL. Serum retinol was positively correlated with optic nerve sheath diameter (ONSD) (r = 0.349, p = 0.001) in glaucoma patients and not associated with any other demographic features or ophthalmic biometric parameters in the NTG patients. Multivariate logistic regression showed that serum retinol (OR = 0.898, 95CI%: 0.851-0.947) was associated with incident NTG. CONCLUSIONS: NTG patients had lower serum retinol concentrations. Serum retinol uniquely associated with NTG makes it a new potential option for the diagnosis and treatment of the disease.
Authors: Judith E A Warner; Alexander J Larson; Prakash Bhosale; Kathleen B Digre; Courtney Henley; Stephen C Alder; Bradley J Katz; Paul S Bernstein Journal: J Neuroophthalmol Date: 2007-12 Impact factor: 3.042
Authors: N López-Riquelme; C Villalba; C Tormo; A Belmonte; C Fernandez; G Torralba; F Hernández Journal: Int Ophthalmol Date: 2014-07-31 Impact factor: 2.031
Authors: Wishal D Ramdas; Roger C W Wolfs; Jessica C Kiefte-de Jong; Albert Hofman; Paulus T V M de Jong; Johannes R Vingerling; Nomdo M Jansonius Journal: Eur J Epidemiol Date: 2012-03-30 Impact factor: 8.082
Authors: Katarzyna Konieczka; Robert Ritch; Carlo Enrico Traverso; Dong Myung Kim; Michael Scott Kook; Augusto Gallino; Olga Golubnitschaja; Carl Erb; Herbert A Reitsamer; Teruyo Kida; Natalia Kurysheva; Ke Yao Journal: EPMA J Date: 2014-07-08 Impact factor: 6.543