Julie A Hong1, Martin Brechbiel2, Jeff Buchsbaum1, Christie A Canaria3, C Norman Coleman1,2, Freddy E Escorcia2,4, Michael Espey1, Charles Kunos5, Frank Lin4, Deepa Narayanan3, Jacek Capala6. 1. Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Dr., Bethesda, MD, 20892, USA. 2. Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA. 3. Small Business Innovation Research Development Center, National Cancer Institute, Bethesda, MD, USA. 4. Molecular Imaging Branch, National Cancer Institute, Bethesda, MD, USA. 5. Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA. 6. Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Dr., Bethesda, MD, 20892, USA. capalaj@mail.nih.gov.
Abstract
BACKGROUND: Radiopharmaceutical targeted therapy (RPT) has been studied for decades; however, recent clinical trials demonstrating efficacy have helped renewed interest in the modality. METHODS: This article reviews National Cancer Institute (NCI)'s support of RPT through communication via workshops and interest groups, through funding extramural programs in academia and small business, and through intramural research, including preclinical and clinical studies. RESULTS: NCI has co-organized workshops and organized interest groups on RPT and RPT dosimetry to encourage the community and facilitate rigorous preclinical and clinical studies. NCI has been supporting RPT research through various mechanisms. Research has been funded through peer-reviewed NCI Research and Program Grants (RPG) and NCI Small Business Innovation Research (SBIR) Development Center, which funds small business-initiated projects, some of which have led to clinical trials. The NCI Cancer Therapy Evaluation Program (CTEP)'s Radiopharmaceutical Development Initiative supports RPT in NCI-funded clinical trials, including Imaging and Radiation Oncology Core (IROC) expertise in imaging QA and dosimetry procedures. Preclinical targeted a-emitter therapy (TAT) research at the NCI's intramural program is ongoing, building on foundational work dating back to the 1980s. Ongoing "bench-to-bedside" efforts leverage the unique infrastructure of the National Institutes of Health's (NIH) Clinical Center. CONCLUSION: Given the great potential of RPT, our goal is to continue to encourage its development that will generate the high-quality evidence needed to bring this multidisciplinary treatment to patients.
BACKGROUND: Radiopharmaceutical targeted therapy (RPT) has been studied for decades; however, recent clinical trials demonstrating efficacy have helped renewed interest in the modality. METHODS: This article reviews National Cancer Institute (NCI)'s support of RPT through communication via workshops and interest groups, through funding extramural programs in academia and small business, and through intramural research, including preclinical and clinical studies. RESULTS: NCI has co-organized workshops and organized interest groups on RPT and RPT dosimetry to encourage the community and facilitate rigorous preclinical and clinical studies. NCI has been supporting RPT research through various mechanisms. Research has been funded through peer-reviewed NCI Research and Program Grants (RPG) and NCI Small Business Innovation Research (SBIR) Development Center, which funds small business-initiated projects, some of which have led to clinical trials. The NCI Cancer Therapy Evaluation Program (CTEP)'s Radiopharmaceutical Development Initiative supports RPT in NCI-funded clinical trials, including Imaging and Radiation Oncology Core (IROC) expertise in imaging QA and dosimetry procedures. Preclinical targeted a-emitter therapy (TAT) research at the NCI's intramural program is ongoing, building on foundational work dating back to the 1980s. Ongoing "bench-to-bedside" efforts leverage the unique infrastructure of the National Institutes of Health's (NIH) Clinical Center. CONCLUSION: Given the great potential of RPT, our goal is to continue to encourage its development that will generate the high-quality evidence needed to bring this multidisciplinary treatment to patients.
Authors: J A Carrasquillo; J L Mulshine; P A Bunn; J C Reynolds; K A Foon; R W Schroff; P Perentesis; R G Steis; A M Keenan; M Horowitz Journal: J Nucl Med Date: 1987-03 Impact factor: 10.057
Authors: D Colcher; J Esteban; J A Carrasquillo; P Sugarbaker; J C Reynolds; G Bryant; S M Larson; J Schlom Journal: Cancer Res Date: 1987-08-01 Impact factor: 12.701
Authors: J A Carrasquillo; K A Krohn; P Beaumier; R W McGuffin; J P Brown; K E Hellström; I Hellström; S M Larson Journal: Cancer Treat Rep Date: 1984-01
Authors: Rositsa Koleva-Kolarova; James Buchanan; Heleen Vellekoop; Simone Huygens; Matthijs Versteegh; Maureen Rutten-van Mölken; László Szilberhorn; Tamás Zelei; Balázs Nagy; Sarah Wordsworth; Apostolos Tsiachristas Journal: Appl Health Econ Health Policy Date: 2022-04-04 Impact factor: 3.686