Literature DB >> 3437766

Evaluation of the antihepatotoxic activity of the biflavonoids of Garcinia kola seed.

M M Iwu1, O A Igboko, U A Onwuchekwa, C O Okunji.   

Abstract

Seeds of Garcinia kola enjoy a folk reputation in Africa as a poison antidote. Their antihepatotoxic properties have been evaluated using four experimental toxins, namely carbon tetrachloride, galactosamine, alpha-amanitin and phalloidin. Kolaviron, a fraction of the defatted ethanol extract, and two biflavones of Garcinia kola seeds (GB1 and GB2) significantly modified the action of all these hepatotoxins. At 100 mg/kg orally, the test substances reduced thiopental-induced sleep in CCl4-poisoned rats. The microsomal enzyme levels in the serum of mice poisoned with phalloidin were significantly protected by treatment with Garcinia extractives. The probable mechanism of the antihepatotoxic action is briefly discussed.

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Year:  1987        PMID： 3437766     DOI： 10.1016/0378-8741(87)90123-1

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  9 in total

1.  Ameliorative effect of kolaviron, a biflavonoid complex from Garcinia kola seeds against scopolamine-induced memory impairment in rats: role of antioxidant defense system.

Authors:  Ismail O Ishola; Folasade M Adamson; Olufunmilayo O Adeyemi
Journal:  Metab Brain Dis       Date:  2016-09-08       Impact factor: 3.584

2.  Kolaviron Improves Morbidity and Suppresses Mortality by Mitigating Oxido-Inflammation in BALB/c Mice Infected with Influenza Virus.

Authors:  Ifeoluwa O Awogbindin; David O Olaleye; Ebenezer O Farombi
Journal:  Viral Immunol       Date:  2015-07-22       Impact factor: 2.257

3.  Some Nigerian anti-tuberculosis ethnomedicines: a preliminary efficacy assessment.

Authors:  Nneka N Ibekwe; John B Nvau; Peters O Oladosu; Auwal M Usman; Kolo Ibrahim; Helena I Boshoff; Cynthia S Dowd; Abayomi T Orisadipe; Olapeju Aiyelaagbe; Akinbo A Adesomoju; Clifton E Barry; Joseph I Okogun
Journal:  J Ethnopharmacol       Date:  2014-06-06       Impact factor: 4.360

4.  Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats.

Authors:  O A Adaramoye
Journal:  Afr Health Sci       Date:  2012-12       Impact factor: 0.927

5.  Kolaviron, a biflavonoid of Garcinia kola seed mitigates ischemic/reperfusion injury by modulation of pro-survival and apoptotic signaling pathways.

Authors:  Ademola Adetokunbo Oyagbemi; Dirk Bester; Johan Esterhuyse; Ebenezer Olatunde Farombi
Journal:  J Intercult Ethnopharmacol       Date:  2016-09-28

6.  Clinical effects of Garcinia kola in knee osteoarthritis.

Authors:  Olayinka O Adegbehingbe; Saburi A Adesanya; Thomas O Idowu; Oluwakemi C Okimi; Oyesiku A Oyelami; Ezekiel O Iwalewa
Journal:  J Orthop Surg Res       Date:  2008-07-30       Impact factor: 2.359

7.  Investigation of effects of time of measurement and modes of administration on cadmium accumulation in rat liver under some medicinal plants food supplemented diet.

Authors:  Chukwuemeka R Nwokocha; Novie Younger-Coleman; Magdalene Nwokocha; Daniel U Owu; Moses Iwuala
Journal:  Pharmacognosy Res       Date:  2014-07

8.  Kolaviron attenuated arsenic acid induced-cardiorenal dysfunction via regulation of ROS, C-reactive proteins (CRP), cardiac troponin I (CTnI) and BCL2.

Authors:  Ademola Adetokunbo Oyagbemi; Temidayo Olutayo Omobowale; Ebunoluwa Racheal Asenuga; John Olusoji Abiola; Adeolu Alex Adedapo; Momoh Audu Yakubu
Journal:  J Tradit Complement Med       Date:  2017-12-07

9.  Effects of Thermal Processing on the Nutritional, Antinutrient, and In Vitro Antioxidant Profile of Monodora myristica (Gaertn.) Dunal Seeds.

Authors:  Anna Ngozi Agiriga; Muthulisi Siwela
Journal:  Prev Nutr Food Sci       Date:  2018-09-30
  9 in total

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