Literature DB >> 34375594

Mucus.

Abigail McShane1, Jade Bath2, Ana M Jaramillo3, Caroline Ridley4, Agnes A Walsh2, Christopher M Evans5, David J Thornton6, Katharina Ribbeck7.   

Abstract

Mucus is a slimy hydrogel that lines the mucosal surfaces in our body, including the intestines, stomach, eyes, lungs and urogenital tract. This glycoprotein-rich network is truly the jack of all trades. As a barrier, it lubricates surfaces, protects our cells from physical stress, and selectively allows the passage of nutrients while clearing out pathogens and debris. As a home to our microbiota, it supports a level of microbial diversity that is unattainable with most culture methods. As a reservoir of complex carbohydrate structures called glycans, it plays critical roles in controlling cell adhesion and signaling, and it alters the behavior and spatial distribution of microbes. On top of all this, mucus regulates the passage of sperm during fertilization, heals wounds, helps us smell, and prevents the stomach from digesting itself, to name just a few of its functions. Given these impressive features, it is no wonder that mucus crosses boundaries of species and kingdoms - mucus gels are made by organisms ranging from the simplest metazoans to corals, snails, fish, and frogs. It is also no surprise that mucus is exploited in everyday applications, including foods, cosmetics, and other products relevant to medicine and industry.
Copyright © 2021. Published by Elsevier Inc.

Entities:  

Mesh:

Year:  2021        PMID: 34375594      PMCID: PMC8759706          DOI: 10.1016/j.cub.2021.06.093

Source DB:  PubMed          Journal:  Curr Biol        ISSN: 0960-9822            Impact factor:   10.834


  15 in total

Review 1.  Muco-Obstructive Lung Diseases.

Authors:  Richard C Boucher
Journal:  N Engl J Med       Date:  2019-05-16       Impact factor: 91.245

Review 2.  Mucins and Their Role in Shaping the Functions of Mucus Barriers.

Authors:  C E Wagner; K M Wheeler; K Ribbeck
Journal:  Annu Rev Cell Dev Biol       Date:  2018-05-11       Impact factor: 13.827

Review 3.  Supramolecular dynamics of mucus.

Authors:  Pedro Verdugo
Journal:  Cold Spring Harb Perspect Med       Date:  2012-11-01       Impact factor: 6.915

Review 4.  Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

Authors:  Eric P Bennett; Ulla Mandel; Henrik Clausen; Thomas A Gerken; Timothy A Fritz; Lawrence A Tabak
Journal:  Glycobiology       Date:  2011-12-18       Impact factor: 4.313

5.  Muc5b is required for airway defence.

Authors:  Michelle G Roy; Alessandra Livraghi-Butrico; Ashley A Fletcher; Melissa M McElwee; Scott E Evans; Ryan M Boerner; Samantha N Alexander; Lindsey K Bellinghausen; Alfred S Song; Youlia M Petrova; Michael J Tuvim; Roberto Adachi; Irlanda Romo; Andrea S Bordt; M Gabriela Bowden; Joseph H Sisson; Prescott G Woodruff; David J Thornton; Karine Rousseau; Maria M De la Garza; Seyed J Moghaddam; Harry Karmouty-Quintana; Michael R Blackburn; Scott M Drouin; C William Davis; Kristy A Terrell; Barbara R Grubb; Wanda K O'Neal; Sonia C Flores; Adela Cota-Gomez; Catherine A Lozupone; Jody M Donnelly; Alan M Watson; Corinne E Hennessy; Rebecca C Keith; Ivana V Yang; Lea Barthel; Peter M Henson; William J Janssen; David A Schwartz; Richard C Boucher; Burton F Dickey; Christopher M Evans
Journal:  Nature       Date:  2013-12-08       Impact factor: 49.962

Review 6.  Mucins in cancer: function, prognosis and therapy.

Authors:  Donald W Kufe
Journal:  Nat Rev Cancer       Date:  2009-12       Impact factor: 60.716

7.  Gel-forming mucins appeared early in metazoan evolution.

Authors:  Tiange Lang; Gunnar C Hansson; Tore Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-02       Impact factor: 11.205

8.  Disruption-induced mucus secretion: repair and protection.

Authors:  K Miyake; T Tanaka; P L McNeil
Journal:  PLoS Biol       Date:  2006-09       Impact factor: 8.029

9.  Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection.

Authors:  Kelsey M Wheeler; Gerardo Cárcamo-Oyarce; Bradley S Turner; Sheri Dellos-Nolan; Julia Y Co; Sylvain Lehoux; Richard D Cummings; Daniel J Wozniak; Katharina Ribbeck
Journal:  Nat Microbiol       Date:  2019-10-14       Impact factor: 17.745

10.  ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.

Authors:  Laura Campbell; Matthew R Hepworth; Jayde Whittingham-Dowd; Seona Thompson; Allison J Bancroft; Kelly S Hayes; Tovah N Shaw; Burton F Dickey; Anne-Laure Flamar; David Artis; David A Schwartz; Christopher M Evans; Ian S Roberts; David J Thornton; Richard K Grencis
Journal:  J Exp Med       Date:  2019-10-03       Impact factor: 14.307

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  4 in total

Review 1.  The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity.

Authors:  Calum C Bain; Andrew S MacDonald
Journal:  Mucosal Immunol       Date:  2022-01-11       Impact factor: 7.313

2.  Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine.

Authors:  Hisanao Kishimoto; Kaori Miyazaki; Hiroshi Tedzuka; Ryosuke Ozawa; Hanai Kobayashi; Yoshiyuki Shirasaka; Katsuhisa Inoue
Journal:  Molecules       Date:  2021-10-22       Impact factor: 4.411

Review 3.  Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects.

Authors:  Lea A Adolf; Simon Heilbronner
Journal:  Metabolites       Date:  2022-05-27

4.  A mechanism of gene evolution generating mucin function.

Authors:  Petar Pajic; Shichen Shen; Jun Qu; Alison J May; Sarah Knox; Stefan Ruhl; Omer Gokcumen
Journal:  Sci Adv       Date:  2022-08-26       Impact factor: 14.957

  4 in total

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