| Literature DB >> 34373969 |
Yun Lan1, Linghua Li1, Weiping Cai1, Junbin Li1, Xizi Deng1, Feng Li1, Chunliang Lei1, Fengyu Hu2, Xiaoping Tang3.
Abstract
Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.Entities:
Year: 2021 PMID: 34373969 DOI: 10.1007/s00705-021-05198-5
Source DB: PubMed Journal: Arch Virol ISSN: 0304-8608 Impact factor: 2.574