Literature DB >> 3437301

Clinical and biochemical effects of gamma-vinyl Gaba in tardive dyskinesia.

J M Gaio1, P Pollak, M Hommel, J Perret.   

Abstract

Clinical and biochemical effects of Gamma-vinyl-Gaba (GVG) have been evaluated in a blind video-controlled study in 10 psychiatric patients (mean age 71 yr) with tardive dyskinesia. CSF free and total Gaba and homocarnosine concentrations increased from three to five fold with GVG treatment. Despite the GVG-induced biological effects on Gaba metabolism, GVG did not consistently improve tardive dyskinesia. Psychomotor side-effects occurred in older patients, who only tolerated GVG dosages of 2-4 g/day.

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Year:  1987        PMID： 3437301      PMCID： PMC1032612          DOI： 10.1136/jnnp.50.12.1674

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  22 in total

1.  Sustained gamma-aminobutyric acid receptor stimulation and chronic neuroleptic effects.

Authors:  K G Lloyd; P Worms
Journal:  Adv Biochem Psychopharmacol       Date:  1980

2.  Nigral-derived muscimol circling--ipsiversive, contraversive or controversial?

Authors:  M S Starr; I C Kilpatrick
Journal:  Nature       Date:  1981-04-16       Impact factor: 49.962

3.  Effects of gamma-vinyl GABA.

Authors:  G P Tell; P J Schechter; J Koch-Weser; P Cantiniaux; J P Chabannes; P A Lambert
Journal:  N Engl J Med       Date:  1981-09-03       Impact factor: 91.245

Review 4.  Management of tardive dyskinesia: current update.

Authors:  G M Simpson; E H Pi; J J Sramek
Journal:  Drugs       Date:  1982-05       Impact factor: 9.546

5.  Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration.

Authors:  G Tell; P Böhlen; P J Schechter; J Koch-Weser; Y Agid; A M Bonnet; G Coquillat; G Chazot; C Fischer
Journal:  Neurology       Date:  1981-02       Impact factor: 9.910

6.  Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid).

Authors:  J Grove; P J Schechter; G Tell; J Koch-Weser; A Sjoerdsma; J M Warter; C Marescaux; L Rumbach
Journal:  Life Sci       Date:  1981-05-21       Impact factor: 5.037

7.  Changes in prevalence, severity, and recovery in tardive dyskinesia with age.

Authors:  J M Smith; R J Baldessarini
Journal:  Arch Gen Psychiatry       Date:  1980-12

8.  Turning behaviour induced by injection of muscimol or picrotoxin into the substantia nigra demonstrates dual GABA components.

Authors:  C Reavill; P Jenner; N Leigh; C D Marsden
Journal:  Neurosci Lett       Date:  1979-05       Impact factor: 3.046

9.  gamma-Acetylenic GABA in tardive dyskinesia.

Authors:  D E Casey; J Gerlach; G Magelund; T R Christensen
Journal:  Arch Gen Psychiatry       Date:  1980-12

10.  Isoniazid-induced elevation of CSF GABA levels and effects on chorea in Huntington's disease.

Authors:  B V Manyam; L Katz; T A Hare; K Kaniefski; R D Tremblay
Journal:  Ann Neurol       Date:  1981-07       Impact factor: 10.422
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  1 in total

1.  Gamma vinyl GABA in the treatment of levodopa-induced dyskinesias in Parkinson's disease.

Authors:  N Turjanski; A J Lees
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-05       Impact factor: 10.154
  1 in total

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