Shigeo Muro1, Hisatoshi Sugiura2, Patrick Darken3, Paul Dorinsky4. 1. Department of Respiratory Medicine, Nara Medical University Graduate School of Medicine, 840 Shijo-cho, Kashihara-shi, 634-8521, Nara, Japan. smuro@naramed-u.ac.jp. 2. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. 3. AstraZeneca, Wilmington, DE, USA. 4. AstraZeneca, Durham, NC, USA.