Toshihide Toriyama1, Yoshiki Hanaoka2, Tetsuyoshi Horiuchi3. 1. Toriyama Clinic, Komoro, Nagano, Japan. 2. Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. hanaoka@shinshu-u.ac.jp. 3. Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Abstract
BACKGROUND: Vestibular migraine (VM) commonly causes episodic vertigo/dizziness; however, its clinical features are unknown. Based on the evidence that central sensitization is related to VM pathogenesis, we hypothesized that cutaneous allodynia is frequently associated with patients with VM compared with patients without VM. This study aims to (1) elucidate the clinical features of patients with VM and (2) evaluate whether patients with VM were more frequently associated with cutaneous allodynia than patients without VM. METHODS: This cross-sectional study enrolled consecutive patients with migraine aged 18-65 years. The comprehensive interview form included diagnostic questions regarding migraine and VM, demographic characteristics, migraine-specific variables, migraine-associated symptoms, and cutaneous allodynia. RESULTS: A total of 245 consecutive patients with migraine (mean age = 39.5 years, 81.2% women) were enrolled; 65 (26.5%) patients with VM were assigned to the VM group, 74 (30.2%) with migraine with vestibular symptoms not meeting the VM criteria (MwVS) were assigned to the MwVS group, and 106 (43.3%) patients with episodic migraine without vestibular symptoms (EM) were assigned to the EM group, respectively. Pairwise comparisons demonstrated no significant differences between the VM and MwVS groups, except for severe disability in the VM group. Compared with EM group, VM group had significant aura, severe disability, depression, tinnitus, sleep disorders, and widespread multimodal cutaneous allodynia. CONCLUSIONS: VM and MwVS may be on the same spectrum of disorders. The VM group had significantly associated widespread multimodal cutaneous allodynia compared with the EM group, indicating that thalamic sensitization plays a key role in VM pathogenesis. Widespread allodynia may be a useful diagnostic aid for VM.
BACKGROUND:Vestibular migraine (VM) commonly causes episodic vertigo/dizziness; however, its clinical features are unknown. Based on the evidence that central sensitization is related to VM pathogenesis, we hypothesized that cutaneous allodynia is frequently associated with patients with VM compared with patients without VM. This study aims to (1) elucidate the clinical features of patients with VM and (2) evaluate whether patients with VM were more frequently associated with cutaneous allodynia than patients without VM. METHODS: This cross-sectional study enrolled consecutive patients with migraine aged 18-65 years. The comprehensive interview form included diagnostic questions regarding migraine and VM, demographic characteristics, migraine-specific variables, migraine-associated symptoms, and cutaneous allodynia. RESULTS: A total of 245 consecutive patients with migraine (mean age = 39.5 years, 81.2% women) were enrolled; 65 (26.5%) patients with VM were assigned to the VM group, 74 (30.2%) with migraine with vestibular symptoms not meeting the VM criteria (MwVS) were assigned to the MwVS group, and 106 (43.3%) patients with episodic migraine without vestibular symptoms (EM) were assigned to the EM group, respectively. Pairwise comparisons demonstrated no significant differences between the VM and MwVS groups, except for severe disability in the VM group. Compared with EM group, VM group had significant aura, severe disability, depression, tinnitus, sleep disorders, and widespread multimodal cutaneous allodynia. CONCLUSIONS: VM and MwVS may be on the same spectrum of disorders. The VM group had significantly associated widespread multimodal cutaneous allodynia compared with the EM group, indicating that thalamic sensitization plays a key role in VM pathogenesis. Widespread allodynia may be a useful diagnostic aid for VM.
Authors: Thomas Lempert; Jes Olesen; Joseph Furman; John Waterston; Barry Seemungal; John Carey; Alexander Bisdorff; Maurizio Versino; Stefan Evers; David Newman-Toker Journal: J Vestib Res Date: 2012 Impact factor: 2.435
Authors: M Kosinski; M S Bayliss; J B Bjorner; J E Ware; W H Garber; A Batenhorst; R Cady; C G H Dahlöf; A Dowson; S Tepper Journal: Qual Life Res Date: 2003-12 Impact factor: 4.147