Helena Brito1, Ana C Santos2,3,4,5, John Preto6, Davide Carvalho7,2,8, Paula Freitas7,2,6,8. 1. Faculdade de Medicina, Universidade do Porto, Porto, Portugal. helena.mbrito@hotmail.com. 2. Instituto de Investigação e Inovação em Saúde (i3s), Universidade do Porto, Porto, Portugal. 3. EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal. 4. Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, Portugal. 5. Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal. 6. Centro de Responsabilidade Integrado de Obesidade (CRIO), Centro Hospitalar Universitário de São João, Porto, Portugal. 7. Faculdade de Medicina, Universidade do Porto, Porto, Portugal. 8. Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar Universitário de São João, Porto, Portugal.
Abstract
INTRODUCTION: Obesity is a significant risk factor for cancer incidence and mortality. The number of patients with obesity who undergo bariatric surgery is increasing; however, the impact of such a procedure in affecting the risk of cancer is not completely understood yet. METHODS: We conducted a retrospective unicentric cohort study to characterize the occurrence of cancer in patients who underwent bariatric surgery from January 2010 to December 2018. For cases of cancer identified after bariatric surgery, we performed a cancer-free survival analysis over time. We also performed a cross-sectional analysis of demographic and clinical characteristics at the time of surgery and compared patients with or without a cancer diagnosis. RESULTS: Of the 2578 patients who underwent bariatric surgery, 117 patients (4.5%) were diagnosed with a cancer. Fifty-nine cases were diagnosed before surgery, and the remaining 58 cases occurred after the bariatric procedure. The prevalence of cancer was more accentuated in women (4.9%) than among men (2.7%). Thyroid and breast cancer were the most frequent before and after bariatric surgery, respectively. On average, patients with cancer diagnosis were older (49.0 vs 43.3 years, p<0.001) and with a lower level of education (7.4 vs 8.6 school years, p=0.002). CONCLUSION: Almost all the cases of cancer identified in this study were obesity-related cancers. Further prospective studies are needed to extend the current knowledge regarding the cancer risk profile of patients who undergo bariatric surgery.
INTRODUCTION: Obesity is a significant risk factor for cancer incidence and mortality. The number of patients with obesity who undergo bariatric surgery is increasing; however, the impact of such a procedure in affecting the risk of cancer is not completely understood yet. METHODS: We conducted a retrospective unicentric cohort study to characterize the occurrence of cancer in patients who underwent bariatric surgery from January 2010 to December 2018. For cases of cancer identified after bariatric surgery, we performed a cancer-free survival analysis over time. We also performed a cross-sectional analysis of demographic and clinical characteristics at the time of surgery and compared patients with or without a cancer diagnosis. RESULTS: Of the 2578 patients who underwent bariatric surgery, 117 patients (4.5%) were diagnosed with a cancer. Fifty-nine cases were diagnosed before surgery, and the remaining 58 cases occurred after the bariatric procedure. The prevalence of cancer was more accentuated in women (4.9%) than among men (2.7%). Thyroid and breast cancer were the most frequent before and after bariatric surgery, respectively. On average, patients with cancer diagnosis were older (49.0 vs 43.3 years, p<0.001) and with a lower level of education (7.4 vs 8.6 school years, p=0.002). CONCLUSION: Almost all the cases of cancer identified in this study were obesity-related cancers. Further prospective studies are needed to extend the current knowledge regarding the cancer risk profile of patients who undergo bariatric surgery.
Authors: Béatrice Lauby-Secretan; Chiara Scoccianti; Dana Loomis; Yann Grosse; Franca Bianchini; Kurt Straif Journal: N Engl J Med Date: 2016-08-25 Impact factor: 91.245
Authors: Maria Kyrgiou; Ilkka Kalliala; Georgios Markozannes; Marc J Gunter; Evangelos Paraskevaidis; Hani Gabra; Pierre Martin-Hirsch; Konstantinos K Tsilidis Journal: BMJ Date: 2017-02-28
Authors: Antonio Buondonno; Pasquale Avella; Micaela Cappuccio; Andrea Scacchi; Roberto Vaschetti; Giancarlo Di Marzo; Pietro Maida; Claudio Luciani; Bruno Amato; Maria Chiara Brunese; Daniela Esposito; Lucio Selvaggi; Germano Guerra; Aldo Rocca Journal: Front Surg Date: 2022-03-24