BACKGROUND: The profound changes wrought by coronavirus disease 2019 (COVID-19) on routine hospital operations may have influenced performance on hospital measures, including healthcare-associated infections (HAIs). We aimed to evaluate the association between COVID-19 surges and HAI and cluster rates. METHODS: In 148 HCA Healthcare-affiliated hospitals, from 1 March 2020 to 30 September 2020, and a subset of hospitals with microbiology and cluster data through 31 December 2020, we evaluated the association between COVID-19 surges and HAIs, hospital-onset pathogens, and cluster rates using negative binomial mixed models. To account for local variation in COVID-19 pandemic surge timing, we included the number of discharges with a laboratory-confirmed COVID-19 diagnosis per staffed bed per month. RESULTS: Central line-associated blood stream infections (CLABSI), catheter-associated urinary tract infections (CAUTI), and methicillin-resistant Staphylococcus aureus (MRSA) bacteremia increased as COVID-19 burden increased. There were 60% (95% confidence interval [CI]: 23-108%) more CLABSI, 43% (95% CI: 8-90%) more CAUTI, and 44% (95% CI: 10-88%) more cases of MRSA bacteremia than expected over 7 months based on predicted HAIs had there not been COVID-19 cases. Clostridioides difficile infection was not significantly associated with COVID-19 burden. Microbiology data from 81 of the hospitals corroborated the findings. Notably, rates of hospital-onset bloodstream infections and multidrug resistant organisms, including MRSA, vancomycin-resistant enterococcus, and Gram-negative organisms, were each significantly associated with COVID-19 surges. Finally, clusters of hospital-onset pathogens increased as the COVID-19 burden increased. CONCLUSIONS: COVID-19 surges adversely impact HAI rates and clusters of infections within hospitals, emphasizing the need for balancing COVID-related demands with routine hospital infection prevention.
BACKGROUND: The profound changes wrought by coronavirus disease 2019 (COVID-19) on routine hospital operations may have influenced performance on hospital measures, including healthcare-associated infections (HAIs). We aimed to evaluate the association between COVID-19 surges and HAI and cluster rates. METHODS: In 148 HCA Healthcare-affiliated hospitals, from 1 March 2020 to 30 September 2020, and a subset of hospitals with microbiology and cluster data through 31 December 2020, we evaluated the association between COVID-19 surges and HAIs, hospital-onset pathogens, and cluster rates using negative binomial mixed models. To account for local variation in COVID-19 pandemic surge timing, we included the number of discharges with a laboratory-confirmed COVID-19 diagnosis per staffed bed per month. RESULTS: Central line-associated blood stream infections (CLABSI), catheter-associated urinary tract infections (CAUTI), and methicillin-resistant Staphylococcus aureus (MRSA) bacteremia increased as COVID-19 burden increased. There were 60% (95% confidence interval [CI]: 23-108%) more CLABSI, 43% (95% CI: 8-90%) more CAUTI, and 44% (95% CI: 10-88%) more cases of MRSA bacteremia than expected over 7 months based on predicted HAIs had there not been COVID-19 cases. Clostridioides difficile infection was not significantly associated with COVID-19 burden. Microbiology data from 81 of the hospitals corroborated the findings. Notably, rates of hospital-onset bloodstream infections and multidrug resistant organisms, including MRSA, vancomycin-resistant enterococcus, and Gram-negative organisms, were each significantly associated with COVID-19 surges. Finally, clusters of hospital-onset pathogens increased as the COVID-19 burden increased. CONCLUSIONS: COVID-19 surges adversely impact HAI rates and clusters of infections within hospitals, emphasizing the need for balancing COVID-related demands with routine hospital infection prevention.
Authors: Christine Geffers; Frank Schwab; Michael Behnke; Petra Gastmeier Journal: Antimicrob Resist Infect Control Date: 2022-05-07 Impact factor: 6.454
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Authors: Claudia Isonne; Valentina Baccolini; Giuseppe Migliara; Mariateresa Ceparano; Francesco Alessandri; Giancarlo Ceccarelli; Guglielmo Tellan; Francesco Pugliese; Maria De Giusti; Corrado De Vito; Carolina Marzuillo; Paolo Villari; Lavinia Camilla Barone; Dara Giannini; Daniela Marotta; Mattia Marte; Elena Mazzalai; Irma Germani; Arianna Bellini; Andrea Bongiovanni; Marta Castellani; Ludovica D'Agostino; Andrea De Giorgi; Chiara De Marchi; Elisa Mazzeo; Shadi Orlandi; Matteo Piattoli; Eleonora Ricci; Leonardo Maria Siena; Alessandro Territo; Stefano Zanni Journal: J Clin Med Date: 2022-03-07 Impact factor: 4.241
Authors: Beatriz Díaz Pollán; Gladys Virginia Guedez López; Paloma María García Clemente; María Jiménez González; Silvia García Bujalance; María Rosa Gómez-Gil Mirá Journal: J Clin Med Date: 2022-03-25 Impact factor: 4.241
Authors: Sulaiman Lakoh; Emmanuel Firima; Christine Ellen Elleanor Williams; Sarah K Conteh; Mohamed Boie Jalloh; Mohamed Gbeshay Sheku; Olukemi Adekanmbi; Stephen Sevalie; Sylvia Adama Kamara; Mohamed Akmed Salim Kamara; Umu Barrie; Gladys Nanilla Kamara; Le Yi; Xuejun Guo; Chukwuemeka Haffner; Matilda N Kamara; Darlinda F Jiba; Enanga Sonia Namanaga; Anna Maruta; Christiana Kallon; Joseph Sam Kanu; Gibrilla F Deen; Mohamed Samai; Joseph Chukwudi Okeibunor; James B W Russell Journal: Trop Med Infect Dis Date: 2021-11-29