Literature DB >> 34368781

Missing the target in cancer therapy.

Jacob J Adashek1, Alexey Goloubev2, Shumei Kato3, Razelle Kurzrock4.   

Abstract

The deployment of molecular biomarkers that are indicative of sensitivity to tumor-targeted or immune-targeted cancer therapies improves the outcome of individual patients and increases the chances of successful drug approval. However, for many lethal malignancies, the majority of clinical trials are conducted with patients who do not have biomarkers and hence they miss the target.

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Year:  2021        PMID: 34368781      PMCID: PMC8336921          DOI: 10.1038/s43018-021-00204-w

Source DB:  PubMed          Journal:  Nat Cancer        ISSN: 2662-1347


  2 in total

Review 1.  From Tissue-Agnostic to N-of-One Therapies: (R)Evolution of the Precision Paradigm.

Authors:  Jacob J Adashek; Vivek Subbiah; Razelle Kurzrock
Journal:  Trends Cancer       Date:  2020-09-29

2.  Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics.

Authors:  Ryosuke Okamura; Amélie Boichard; Shumei Kato; Jason K Sicklick; Lyudmila Bazhenova; Razelle Kurzrock
Journal:  JCO Precis Oncol       Date:  2018-11-15
  2 in total
  3 in total

Review 1.  First-line Immune Checkpoint Inhibitor Combinations in Metastatic Renal Cell Carcinoma: Where Are We Going, Where Have We Been?

Authors:  Jacob J Adashek; Joshua J Breunig; Edwin Posadas; Neil A Bhowmick; Leigh Ellis; Stephen J Freedland; Hyung Kim; Robert Figlin; Jun Gong
Journal:  Drugs       Date:  2022-02-17       Impact factor: 9.546

Review 2.  Genomics and Immunomics in the Treatment of Urothelial Carcinoma.

Authors:  Veronica Mollica; Francesco Massari; Alessandro Rizzo; Roberto Ferrara; Arjun K Menta; Jacob J Adashek
Journal:  Curr Oncol       Date:  2022-05-12       Impact factor: 3.109

Review 3.  Dermatologic Disease-Directed Targeted Therapy (D3T2): The Application of Biomarker-Based Precision Medicine for the Personalized Treatment of Skin Conditions-Precision Dermatology.

Authors:  Philip R Cohen; Razelle Kurzrock
Journal:  Dermatol Ther (Heidelb)       Date:  2022-09-19
  3 in total

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