Heike Rabe1, Varsha Bhatt-Mehta2, Stephen A Bremner3, Aisling Ahluwalia3, Renske Mcfarlane3, Simin Baygani4, Beau Batton5, Agnes Klein6, Ebru Ergenekon7, Luana Pesco Koplowitz8, Eugene Dempsey9, Dina Apele-Freimane10, Hiroko Iwami11, Janis M Dionne12. 1. Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Heike.Rabe@nhs.net. 2. FDA Center for Drug Evaluation and Research, Virginia, MD, USA. 3. Brighton and Sussex Medical School, University of Sussex, Brighton, UK. 4. Eli Lilly and Company, Indianapolis, IN, USA. 5. Southern Illinois University School of Medicine, Springfield, IL, USA. 6. Health Canada, Ottawa, ON, Canada. 7. Gazi University, Ankara, Turkey. 8. DUCK FLATS Pharma LLC, New York, NY, USA. 9. University College Cork, Cork, Ireland. 10. Pauls Stradins clinical university Hospital, Marupe, Latvia. 11. Osaka City General Hospital, Osaka, Japan. 12. British Columbia Children´s Hospital, Vancouver, BC, Canada.
Abstract
OBJECTIVE: A comprehensive understanding of the factors contributing to perinatal blood pressure is vital to ensure optimal postnatal hemodynamic support. The objective of this study was to review existing literature on maternal and perinatal factors influencing blood pressure in neonates up to 3 months corrected age. METHODS: A systematic search of published literature in OVID Medline, OVID Embase and the COCHRANE library identified publications relating to maternal factors affecting blood pressure of neonates up to corrected age of 3 months. Summary data were extracted and compared (PROSPERO CRD42018092886). RESULTS: Of the 3683 non-duplicate publications identified, 44 were eligible for inclusion in this review. Topics elicited were sociodemographic factors, maternal health status, medications, smoking during pregnancy, and cord management at birth. Limited data were available for each factor. Results regarding the impact of these factors on neonatal blood pressure were inconsistent across studies. CONCLUSIONS: There is insufficient evidence to draw definitive conclusions regarding the impact of various maternal and perinatal factors on neonatal blood pressure. Future investigations of neonatal cardiovascular therapies should account for these factors in their study design. Similarly, studies on maternal diseases and perinatal interventions should include neonatal blood pressure as part of their primary or secondary analyses.
OBJECTIVE: A comprehensive understanding of the factors contributing to perinatal blood pressure is vital to ensure optimal postnatal hemodynamic support. The objective of this study was to review existing literature on maternal and perinatal factors influencing blood pressure in neonates up to 3 months corrected age. METHODS: A systematic search of published literature in OVID Medline, OVID Embase and the COCHRANE library identified publications relating to maternal factors affecting blood pressure of neonates up to corrected age of 3 months. Summary data were extracted and compared (PROSPERO CRD42018092886). RESULTS: Of the 3683 non-duplicate publications identified, 44 were eligible for inclusion in this review. Topics elicited were sociodemographic factors, maternal health status, medications, smoking during pregnancy, and cord management at birth. Limited data were available for each factor. Results regarding the impact of these factors on neonatal blood pressure were inconsistent across studies. CONCLUSIONS: There is insufficient evidence to draw definitive conclusions regarding the impact of various maternal and perinatal factors on neonatal blood pressure. Future investigations of neonatal cardiovascular therapies should account for these factors in their study design. Similarly, studies on maternal diseases and perinatal interventions should include neonatal blood pressure as part of their primary or secondary analyses.