Literature DB >> 3436525

Linkage between the beta B2 and beta B3 crystallin genes in man and rat: a remnant of an ancient beta-crystallin gene cluster.

H J Aarts1, J T Den Dunnen, N H Lubsen, J G Schoenmakers.   

Abstract

Human and rat genomic clones containing beta B2- and/or beta B3-crystallin sequences have been isolated and characterized. Both in the human and the rat genome the single-copy beta B3-crystallin gene is linked to a beta B2-crystallin gene. In both species the linked genes, separated by 20 kb in the human and 11 kb in the rat genome, are oriented head-to-tail with respect to transcription. A single copy of the beta B2-crystallin gene is present in the rat genome, in the human genome two copies of this gene are found. The second human copy could as yet not be linked to the beta B2/beta B3-crystallin gene cluster.

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Year:  1987        PMID： 3436525     DOI： 10.1016/0378-1119(87)90273-3

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  4 in total

Review 1.  A superfamily in the mammalian eye lens: the beta/gamma-crystallins.

Authors:  G L van Rens; W W de Jong; H Bloemendal
Journal:  Mol Biol Rep       Date:  1992-02       Impact factor: 2.316

2.  Amino acid sequence of human lens beta B2-crystallin.

Authors:  L R Miesbauer; J B Smith; D L Smith
Journal:  Protein Sci       Date:  1993-02       Impact factor: 6.725

3.  Different evolution rates within the lens-specific beta-crystallin gene family.

Authors:  H J Aarts; E H Jacobs; G van Willigen; N H Lubsen; J G Schoenmakers
Journal:  J Mol Evol       Date:  1989-04       Impact factor: 2.395

4.  Presence of hybridizing DNA sequences homologous to bovine acidic and basic beta-crystallins in all classes of vertebrates.

Authors:  G L van Rens; F A Hol; W W de Jong; H Bloemendal
Journal:  J Mol Evol       Date:  1991-11       Impact factor: 2.395
  4 in total

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