Jesper Nyman1,2, Manne Holm1,2, Thomas Fux1,2, Vanja Sesartic1,2, Magnus Fredby1,2, Peter Svenarud2,3, Jan van der Linden1,2. 1. Division of Perioperative Medicine and Intensive Care, Section Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden. 2. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 3. Department of Cardiothoracic Surgery, Karolinska University Hospital, Stockholm, Sweden.
Abstract
OBJECTIVES: Carbon dioxide (CO2) gas insufflation is used for continuous de-airing during open heart surgery. The aim was to evaluate if an additional separate venous reservoir eliminates CO2 insufflation-induced hypercapnia and keeps sweep gas flow of the oxygenator constant. METHODS: A separate reservoir was used during cardiopulmonary bypass in addition to a standard venous reservoir. The additional reservoir received drained blood and CO2 gas continuously via a suction drain (1 l/min) and handheld suction devices from the surgical wound. CO2 gas was insufflated via a gas diffuser in the open wound at 10 l/min. In a cross-over design for each patient, gas and blood were either continuously drained from the additional to the standard venous reservoir or not. CO2 pressure in arterial blood (PaCO2) was measured after adjustment of sweep gas flow as necessary and after steady state of PaCO2 was observed. Mean values for each setup (median 4 times) for each patient were analysed with Wilcoxon rank-sum test. RESULTS: Ten adult patients undergoing open aortic valve replacement were included. Median PaCO2 did not differ between setups (5.41; 5.29-5.57, interquartile range vs 5.41; 5.24-5.58, P = 0.92), whereas sweep gas flow (l/min) was lower (2.58; 2.50-3.16 vs 4.42; 4.0-5.40, P = 0.002) when CO2 gas was not drained from the additional to the standard reservoir. CONCLUSIONS: An additional venous reservoir for the evacuation of blood from the open surgical wound eliminates CO2 insufflation-induced hypercapnia in open heart surgery keeping PaCO2 and sweep gas flow constant. This prevents possible CO2-induced hyperperfusion of the brain and decreases the risk of cerebral particulate embolization during CO2 insufflation for de-airing in open heart surgery. CLINICAL TRIAL REGISTRATION: NCT04202575. IRB APPROVAL DAT AND NUMBER: 2018-07-13 and 2018/1091-31.
OBJECTIVES: Carbon dioxide (CO2) gas insufflation is used for continuous de-airing during open heart surgery. The aim was to evaluate if an additional separate venous reservoir eliminates CO2 insufflation-induced hypercapnia and keeps sweep gas flow of the oxygenator constant. METHODS: A separate reservoir was used during cardiopulmonary bypass in addition to a standard venous reservoir. The additional reservoir received drained blood and CO2 gas continuously via a suction drain (1 l/min) and handheld suction devices from the surgical wound. CO2 gas was insufflated via a gas diffuser in the open wound at 10 l/min. In a cross-over design for each patient, gas and blood were either continuously drained from the additional to the standard venous reservoir or not. CO2 pressure in arterial blood (PaCO2) was measured after adjustment of sweep gas flow as necessary and after steady state of PaCO2 was observed. Mean values for each setup (median 4 times) for each patient were analysed with Wilcoxon rank-sum test. RESULTS: Ten adult patients undergoing open aortic valve replacement were included. Median PaCO2 did not differ between setups (5.41; 5.29-5.57, interquartile range vs 5.41; 5.24-5.58, P = 0.92), whereas sweep gas flow (l/min) was lower (2.58; 2.50-3.16 vs 4.42; 4.0-5.40, P = 0.002) when CO2 gas was not drained from the additional to the standard reservoir. CONCLUSIONS: An additional venous reservoir for the evacuation of blood from the open surgical wound eliminates CO2 insufflation-induced hypercapnia in open heart surgery keeping PaCO2 and sweep gas flow constant. This prevents possible CO2-induced hyperperfusion of the brain and decreases the risk of cerebral particulate embolization during CO2 insufflation for de-airing in open heart surgery. CLINICAL TRIAL REGISTRATION: NCT04202575. IRB APPROVAL DAT AND NUMBER: 2018-07-13 and 2018/1091-31.
Authors: J P Dalmas; A Eker; C Girard; C Flamens; J Neidecker; J F Obadia; P Montagna; J J Lehot; O Jegaden; P Mikaeloff Journal: J Heart Valve Dis Date: 1996-09