Literature DB >> 34360919

Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer.

Sakshi Taneja1, Stefan W Vetter1, Estelle Leclerc1.   

Abstract

Hypoxia is characterized by an inadequate supply of oxygen to tissues, and hypoxic regions are commonly found in solid tumors. The cellular response to hypoxic conditions is mediated through the activation of hypoxia-inducible factors (HIFs) that control the expression of a large number of target genes. Recent studies have shown that the receptor for advanced glycation end products (RAGE) participates in hypoxia-dependent cellular adaptation. We review recent evidence on the role of RAGE signaling in tumor biology under hypoxic conditions.

Entities:  

Keywords:  HIF-1α; HMGB1; RAGE; S100 proteins; cancer; hypoxia

Year:  2021        PMID： 34360919     DOI： 10.3390/ijms22158153

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  4 in total

Review 1.  The RAGE/multiligand axis: a new actor in tumor biology.

Authors:  Armando Rojas; Ivan Schneider; Cristian Lindner; Ileana Gonzalez; Miguel A Morales
Journal:  Biosci Rep       Date:  2022-07-29       Impact factor: 3.976

2.  HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells.

Authors:  Kamolporn Amornsupak; Suyanee Thongchot; Chanida Thinyakul; Carol Box; Somaieh Hedayat; Peti Thuwajit; Suzanne A Eccles; Chanitra Thuwajit
Journal:  BMC Cancer       Date:  2022-05-24       Impact factor: 4.638

3.  On the Immunometabolic Role of NF-κB in Adipocytes.

Authors:  Michael J Griffin
Journal:  Immunometabolism       Date:  2022-01-29

4.  Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.

Authors:  Cuifang Ye; Huan Li; Yachao Li; Yang Zhang; Guohao Liu; Hailong Mi; Honglian Li; Qungen Xiao; Li Niu; Xingjiang Yu
Journal:  iScience       Date:  2022-08-04
  4 in total

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