The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results: Patients with COVID-19 exhibited low O3I (mean: 4.15%; range: 3.06-6.14%)-consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean: 7.84%; range: 4.65-10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I.: 0.211-0.997) and death (OR = 0.28; C.I.: 0.08-0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors. Conclusion: We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19.
The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results:Patients with COVID-19 exhibited low O3I (mean: 4.15%; range: 3.06-6.14%)-consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean: 7.84%; range: 4.65-10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I.: 0.211-0.997) and death (OR = 0.28; C.I.: 0.08-0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors. Conclusion: We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19.
Authors: Muriel Ramírez-Santana; Rodrigo Zapata Barra; Marcela Ñunque González; José Miguel Müller; Juan Enrique Vásquez; Franco Ravera; Gustavo Lago; Eduardo Cañón; Daniella Castañeda; Madelaine Pradenas Journal: Int J Environ Res Public Health Date: 2022-05-25 Impact factor: 4.614
Authors: Bruna Teixeira da Costa; Glauber Rocha Lima Araújo; Ronaldo Teixeira da Silva Júnior; Luana Kauany de Sá Santos; Vinícius Lima de Souza Gonçalves; Daniel Bastos Alves Lima; Beatriz Rocha Cuzzuol; Jonathan Santos Apolonio; Lorena Sousa de Carvalho; Hanna Santos Marques; Camilo Santana Silva; Isadora de Souza Barcelos; Márcio Vasconcelos Oliveira; Fabrício Freire de Melo Journal: World J Crit Care Med Date: 2022-07-09