Literature DB >> 34358977

Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder.

Ivy F Tso1, Cynthia Z Burton2, Carly A Lasagna2, Saige Rutherford3, Beier Yao4, Scott J Peltier5, Timothy D Johnson6, Melvin G McInnis2, Stephan F Taylor2.   

Abstract

Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.
Copyright © 2021 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Bipolar disorder; Social cognition; fMRI

Mesh：

Year:  2021        PMID： 34358977      PMCID： PMC8387449          DOI： 10.1016/j.pscychresns.2021.111340

Source DB:  PubMed          Journal:  Psychiatry Res Neuroimaging        ISSN： 0925-4927            Impact factor:   2.493


  17 in total

1.  Social cognition and the brain: a meta-analysis.

Authors:  Frank Van Overwalle
Journal:  Hum Brain Mapp       Date:  2009-03       Impact factor: 5.038

2.  Differential impairment of social cognition factors in bipolar disorder with and without psychotic features and schizophrenia.

Authors:  Nicholas S Thaler; Daniel N Allen; Griffin P Sutton; Mary Vertinski; Erik N Ringdahl
Journal:  J Psychiatr Res       Date:  2013-09-30       Impact factor: 4.791

Review 3.  Understanding the minds of others: A neuroimaging meta-analysis.

Authors:  Pascal Molenberghs; Halle Johnson; Julie D Henry; Jason B Mattingley
Journal:  Neurosci Biobehav Rev       Date:  2016-04-09       Impact factor: 8.989

4.  Eye gaze perception in bipolar disorder: Self-referential bias but intact perceptual sensitivity.

Authors:  Beier Yao; Savanna A Mueller; Tyler B Grove; Merranda McLaughlin; Katharine Thakkar; Vicki Ellingrod; Melvin G McInnis; Stephan F Taylor; Patricia J Deldin; Ivy F Tso
Journal:  Bipolar Disord       Date:  2017-11-23       Impact factor: 6.744

5.  Functional imaging of 'theory of mind'

Authors:  Helen L. Gallagher; Christopher D. Frith
Journal:  Trends Cogn Sci       Date:  2003-02       Impact factor: 20.229

6.  A functional MRI study of Theory of Mind in euthymic bipolar disorder patients.

Authors:  Gin S Malhi; Jim Lagopoulos; Pritha Das; Kirsteen Moss; Michael Berk; Carissa M Coulston
Journal:  Bipolar Disord       Date:  2008-12       Impact factor: 6.744

Review 7.  Meta-analysis of Theory of Mind (ToM) impairment in bipolar disorder.

Authors:  E Bora; C Bartholomeusz; C Pantelis
Journal:  Psychol Med       Date:  2015-10-12       Impact factor: 7.723

8.  Social cognition in schizophrenia: an NIMH workshop on definitions, assessment, and research opportunities.

Authors:  Michael F Green; David L Penn; Richard Bentall; William T Carpenter; Wolfgang Gaebel; Ruben C Gur; Ann M Kring; Sohee Park; Steven M Silverstein; Robert Heinssen
Journal:  Schizophr Bull       Date:  2008-01-08       Impact factor: 9.306

Review 9.  The neural basis of mentalizing.

Authors:  Chris D Frith; Uta Frith
Journal:  Neuron       Date:  2006-05-18       Impact factor: 17.173

10.  Dysfunctional gaze processing in bipolar disorder.

Authors:  Cristina Berchio; Camille Piguet; Christoph M Michel; Paolo Cordera; Tonia A Rihs; Alexandre G Dayer; Jean-Michel Aubry
Journal:  Neuroimage Clin       Date:  2017-09-06       Impact factor: 4.881
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