| Literature DB >> 34358546 |
Christopher B Ryder1, Hannah C Kondolf2, Meghan E O'Keefe2, Bowen Zhou2, Derek W Abbott3.
Abstract
Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune responses and causes tissue damage. Gasdermin (GSDM) proteins are a family of pore-forming executors of pyroptosis. While the most-studied member, GSDMD, exerts critical functions in inflammasome biology, emerging evidence demonstrates potential broad relevance for GSDM-mediated pyroptosis across diverse pathologies. In this review, we describe GSDM biology, outline conditions where inflammasomes and GSDM-mediated pyroptosis represent rational therapeutic targets, and delineate strategies to manipulate these central immunologic processes for the treatment of human disease.Entities:
Keywords: anti-tumor immunity; immunogenic cell death; inflammasome; inflammasomopathy; pore-forming protein
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Year: 2021 PMID： 34358546 PMCID： PMC8810912 DOI： 10.1016/j.jmb.2021.167183
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469