Literature DB >> 34357323

Effects of Statins on Renin-Angiotensin System.

Nasim Kiaie1, Armita Mahdavi Gorabi1, Željko Reiner2, Tannaz Jamialahmadi3,4, Massimiliano Ruscica5, Amirhossein Sahebkar6,7,8,9.   

Abstract

Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin-angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.

Entities:  

Keywords:  hypertension; renin–angiotensin system (RAS); statins

Year:  2021        PMID： 34357323     DOI： 10.3390/jcdd8070080

Source DB:  PubMed          Journal:  J Cardiovasc Dev Dis        ISSN： 2308-3425


  126 in total

1.  Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects.

Authors:  Rene Baudrand; Luminita H Pojoga; Anand Vaidya; Amanda E Garza; Paul A Vöhringer; Xavier Jeunemaitre; Paul N Hopkins; Tham M Yao; Jonathan Williams; Gail K Adler; Gordon H Williams
Journal:  Circulation       Date:  2015-10-02       Impact factor: 29.690

2.  Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men.

Authors:  G Nickenig; A T Bäumer; Y Temur; D Kebben; F Jockenhövel; M Böhm
Journal:  Circulation       Date:  1999-11-23       Impact factor: 29.690

Review 3.  Benefits and Risks of Continuing Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Antagonists, and Mineralocorticoid Receptor Antagonists during Hospitalizations for Acute Heart Failure.

Authors:  Estefania Oliveros; Ebenezer T Oni; Anum Shahzad; Aaron Y Kluger; Kevin Bryan Lo; Janani Rangaswami; Peter A McCullough
Journal:  Cardiorenal Med       Date:  2020-02-14       Impact factor: 2.041

4.  Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons.

Authors:  Robert C Bucelli; Eugene A Gonsiorek; Woo-Yang Kim; Donald Bruun; Richard A Rabin; Dennis Higgins; Pamela J Lein
Journal:  J Pharmacol Exp Ther       Date:  2007-12-13       Impact factor: 4.030

5.  Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.

Authors:  Tao Sun; Daqing Jiang; Liang Zhang; Qinglong Su; Wanli Mao; Cui Jiang
Journal:  Oncol Lett       Date:  2015-11-23       Impact factor: 2.967

6.  In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.

Authors:  Xiao-Jing Zhang; Juan-Juan Qin; Xu Cheng; Lijun Shen; Yan-Ci Zhao; Yufeng Yuan; Fang Lei; Ming-Ming Chen; Huilin Yang; Liangjie Bai; Xiaohui Song; Lijin Lin; Meng Xia; Feng Zhou; Jianghua Zhou; Zhi-Gang She; Lihua Zhu; Xinliang Ma; Qingbo Xu; Ping Ye; Guohua Chen; Liming Liu; Weiming Mao; Youqin Yan; Bing Xiao; Zhigang Lu; Gang Peng; Mingyu Liu; Jun Yang; Luyu Yang; Changjiang Zhang; Haofeng Lu; Xigang Xia; Daihong Wang; Xiaofeng Liao; Xiang Wei; Bing-Hong Zhang; Xin Zhang; Juan Yang; Guang-Nian Zhao; Peng Zhang; Peter P Liu; Rohit Loomba; Yan-Xiao Ji; Jiahong Xia; Yibin Wang; Jingjing Cai; Jiao Guo; Hongliang Li
Journal:  Cell Metab       Date:  2020-06-24       Impact factor: 27.287

7.  COVID-19 and RAS: Unravelling an Unclear Relationship.

Authors:  Damiano D'Ardes; Andrea Boccatonda; Ilaria Rossi; Maria Teresa Guagnano; Francesca Santilli; Francesco Cipollone; Marco Bucci
Journal:  Int J Mol Sci       Date:  2020-04-24       Impact factor: 5.923

Review 8.  Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications.

Authors:  Armita Mahdavi Gorabi; Nasim Kiaie; Saeideh Hajighasemi; Maciej Banach; Peter E Penson; Tannaz Jamialahmadi; Amirhossein Sahebkar
Journal:  J Clin Med       Date:  2019-11-22       Impact factor: 4.241

9.  Statin use is associated with lower disease severity in COVID-19 infection.

Authors:  Wilnard Y T Tan; Barnaby E Young; David Chien Lye; Daniel E K Chew; Rinkoo Dalan
Journal:  Sci Rep       Date:  2020-10-15       Impact factor: 4.379

10.  Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis.

Authors:  Raimundo Fernandes de Araújo Júnior; Tatiana Oliveira Souza; Lígia Moreno de Moura; Kerginaldo Paulo Torres; Lélia Batista de Souza; Maria do Socorro Costa Feitosa Alves; Hugo Oliveira Rocha; Aurigena Antunes de Araújo
Journal:  PLoS One       Date:  2013-10-10       Impact factor: 3.240
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  1 in total

1.  Strong relationship between cholesterol, low-density lipoprotein receptor, Na+/H+ exchanger, and SARS-COV-2: this association may be the cause of death in the patient with COVID-19.

Authors:  Erkan Cure; Medine Cumhur Cure
Journal:  Lipids Health Dis       Date:  2021-12-13       Impact factor: 3.876
  1 in total

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