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Literature DB >> 3435695

Adenosine causes transient dilatation of coronary arteries in man.

A H Watt¹, W J Penny, H Singh, P A Routledge, A H Henderson.

Abstract

We investigated the effects of i.v. adenosine on coronary blood flow in 10 normal subjects undergoing investigation for chest pain. Coronary flow transiently doubled after greater than or equal to 3.5 mg adenosine without increase in perfusion pressure, systolic load or inotropic state at a constant, paced heart rate. The data provide direct evidence that adenosine dilates coronary arteries in man. The transience of the effect suggests a possible role for adenosine in repeated estimations of coronary flow reserve.

Entities: Chemical Disease Species

Mesh：

Substances：
Adenosine

Year: 1987 PMID： 3435695 PMCID： PMC1386340 DOI： 10.1111/j.1365-2125.1987.tb03227.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

26 in total

1. Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart.

Authors: G F Merrill; F J Haddy; J M Dabney
Journal: Circ Res Date: 1978-02 Impact factor: 17.367

2. Myocardial adenosine formation with increased cardiac performance in the dog.

Authors: W P Watkinson; D H Foley; R Rubio; R M Berne
Journal: Am J Physiol Date: 1979-01

Review 3. The role of adenosine in the regulation of coronary blood flow.

Authors: R M Berne
Journal: Circ Res Date: 1980-12 Impact factor: 17.367

4. Release of adenosine from anoxic hearts. Relationship to coronary flow.

Authors: M Katori; R M Berne
Journal: Circ Res Date: 1966-08 Impact factor: 17.367

5. Release of adenosine from human hearts during angina induced by rapid atrial pacing.

Authors: A C Fox; G E Reed; E Glassman; A J Kaltman; B B Silk
Journal: J Clin Invest Date: 1974-05 Impact factor: 14.808

6. Left ventricular contractility and developed tension in the intact dog submitted to an intracoronary infusion of adenosine.

Authors: J Lammerant; I Becsei
Journal: J Physiol Date: 1973-02 Impact factor: 5.182

7. Adenosine-induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body?

Authors: A H Watt; P G Reid; M R Stephens; P A Routledge
Journal: Br J Clin Pharmacol Date: 1987-04 Impact factor: 4.335

8. Coronary vasoactivity of adenosine in the conscious dog.

Authors: R A Olsson; E M Khouri; J L Bedynek; J McLean
Journal: Circ Res Date: 1979-10 Impact factor: 17.367

9. Effect of adenosine on transmural myocardial blood flow distribution in the awake dog.

Authors: J C Rembert; L M Boyd; W P Watkinson; J C Greenfield
Journal: Am J Physiol Date: 1980-07

10. Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia.

Authors: J Schrader; F J Haddy; E Gerlach
Journal: Pflugers Arch Date: 1977-05-06 Impact factor: 3.657

6 in total

Review 5. Adenosine. An evaluation of its use in cardiac diagnostic procedures, and in the treatment of paroxysmal supraventricular tachycardia.

Authors: D Faulds; P Chrisp; M M Buckley
Journal: Drugs Date: 1991-04 Impact factor: 9.546

Review 6. Adenosine and adenosine receptor-mediated action in coronary microcirculation.

Authors: Ying Zhang; Bernhard Wernly; Xin Cao; S Jamal Mustafa; Yong Tang; Zhichao Zhou
Journal: Basic Res Cardiol Date: 2021-03-23 Impact factor: 17.165