| Literature DB >> 3435569 |
N Rothfield1, D Whitaker, B Bordwell, E Weiner, J L Senecal, W Earnshaw.
Abstract
A solid-phase enzyme-linked immunosorbent assay has been established using a cloned fusion protein, CtermCENP-B [beta-gal], as antigen. The fusion protein carries the major epitope of CENP-B, the major centromeric autoantigen. The enzyme-linked immunosorbent assay was more sensitive than immunofluorescence techniques in detecting anticentromere antibodies in patients with scleroderma or Raynaud's disease, and was weakly positive in 3% of normal controls and in 3% of 70 patients with other connective tissue diseases.Entities:
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Year: 1987 PMID： 3435569 DOI： 10.1002/art.1780301214
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591