Brenna A Cholerton1, Kathleen L Poston2, Laurice Yang2, Liana S Rosenthal3, Ted M Dawson3,4,5,6, Alexander Pantelyat3, Karen L Edwards7, Lu Tian8, Joseph F Quinn9,10, Kathryn A Chung9,10, Amie L Hiller9,10, Shu-Ching Hu11,12, Thomas J Montine1, Cyrus P Zabetian11,12. 1. Department of Pathology, Stanford University School of Medicine, Palo Alto, CA, USA. 2. Department of Neurology and Neurological Sciences, Stanford School of Medicine, Palo Alto, CA, USA. 3. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 4. Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 7. Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USA. 8. Department of Biomedical Data Science, Stanford University School of Medicine, Palo Alto, CA, USA. 9. Parkinson's Disease Research, Education, and Clinical Center, Portland Veterans Affairs Health Care System, Portland, OR, USA. 10. Department of Neurology, Oregon Health and Science University, Portland, OR, USA. 11. Geriatric Research Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. 12. Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Abstract
Introduction: Parkinson's disease (PD) is associated with a range of cognitive deficits. Few studies have carefully examined the subtle impacts of PD on cognition among patients who do not meet formal criteria for MCI or dementia. The aim of the current study was thus to describe the impact of PD on cognition in those without cognitive impairment in a well-characterized cohort. Methods: Non-cognitively impaired participants (122 with PD, 122 age- and sex-matched healthy volunteers) underwent extensive cognitive testing. Linear regression analyses compared diagnostic group performance across cognitive measures. For cognitive tasks that were significantly different between groups, additional analyses examined group differences restricting the group inclusion to PD participants with mild motor symptoms or disease duration less than 10 years. Results: Processing speed and semantic verbal fluency were significantly lower in the PD group (B = -3.77, 95% CIs [-5.76 to -1.77], p < .001, and B = -2.02, 95% CIs [-3.12, -0.92], p < .001, respectively), even after excluding those with moderate to severe motor symptoms (B = -2.73, 95% CIs [-4.94 to -0.53], p = .015 and B = -2.11, 95% CIs [-3.32 to -0.91], p < .001, respectively) or longer disease duration (B = -3.89, 95% CIs [-6.14 to -1.63], p < .001 and B = -1.58, 95% CIs [-2.78 to -0.37], p = .010, respectively). Semantic verbal fluency remained significantly negatively associated with PD diagnosis after controlling for processing speed (B = -1.66, 95% CIs [-2.79 to -0.53], p = .004).Conclusions: Subtle decline in specific cognitive domains may be present among people diagnosed with PD but without evidence to support a formal cognitive diagnosis. These results suggest the importance of early awareness of the potential for diminishing aspects of cognition in PD even among those without mild cognitive impairment or dementia.
Introduction: Parkinson's disease (PD) is associated with a range of cognitive deficits. Few studies have carefully examined the subtle impacts of PD on cognition among patients who do not meet formal criteria for MCI or dementia. The aim of the current study was thus to describe the impact of PD on cognition in those without cognitive impairment in a well-characterized cohort. Methods: Non-cognitively impaired participants (122 with PD, 122 age- and sex-matched healthy volunteers) underwent extensive cognitive testing. Linear regression analyses compared diagnostic group performance across cognitive measures. For cognitive tasks that were significantly different between groups, additional analyses examined group differences restricting the group inclusion to PD participants with mild motor symptoms or disease duration less than 10 years. Results: Processing speed and semantic verbal fluency were significantly lower in the PD group (B = -3.77, 95% CIs [-5.76 to -1.77], p < .001, and B = -2.02, 95% CIs [-3.12, -0.92], p < .001, respectively), even after excluding those with moderate to severe motor symptoms (B = -2.73, 95% CIs [-4.94 to -0.53], p = .015 and B = -2.11, 95% CIs [-3.32 to -0.91], p < .001, respectively) or longer disease duration (B = -3.89, 95% CIs [-6.14 to -1.63], p < .001 and B = -1.58, 95% CIs [-2.78 to -0.37], p = .010, respectively). Semantic verbal fluency remained significantly negatively associated with PD diagnosis after controlling for processing speed (B = -1.66, 95% CIs [-2.79 to -0.53], p = .004).Conclusions: Subtle decline in specific cognitive domains may be present among people diagnosed with PD but without evidence to support a formal cognitive diagnosis. These results suggest the importance of early awareness of the potential for diminishing aspects of cognition in PD even among those without mild cognitive impairment or dementia.
Authors: M A Hely; J G Morris; R Traficante; W G Reid; D J O'Sullivan; P M Williamson Journal: J Neurol Neurosurg Psychiatry Date: 1999-09 Impact factor: 10.154
Authors: Raquel P Barbosa; Marcelo D Mendonça; André P Caetano; Tania M Lampreia; Rita Miguel; Paulo M Bugalho Journal: J Neural Transm (Vienna) Date: 2019-07-05 Impact factor: 3.575
Authors: Brenna Cholerton; Michael W Weiner; Rachel L Nosheny; Kathleen L Poston; R Scott Mackin; Lu Tian; J Wesson Ashford; Thomas J Montine Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Janneke Koerts; Hester A Meijer; Katrien S F Colman; Lara Tucha; Klaus W Lange; Oliver Tucha Journal: J Neural Transm (Vienna) Date: 2012-08-26 Impact factor: 3.575
Authors: Christopher G Goetz; Barbara C Tilley; Stephanie R Shaftman; Glenn T Stebbins; Stanley Fahn; Pablo Martinez-Martin; Werner Poewe; Cristina Sampaio; Matthew B Stern; Richard Dodel; Bruno Dubois; Robert Holloway; Joseph Jankovic; Jaime Kulisevsky; Anthony E Lang; Andrew Lees; Sue Leurgans; Peter A LeWitt; David Nyenhuis; C Warren Olanow; Olivier Rascol; Anette Schrag; Jeanne A Teresi; Jacobus J van Hilten; Nancy LaPelle Journal: Mov Disord Date: 2008-11-15 Impact factor: 10.338
Authors: Liana S Rosenthal; Yekaterina A Salnikova; Gregory M Pontone; Alexander Pantelyat; Kelly A Mills; E Ray Dorsey; Jiangxia Wang; Samuel S Wu; Zoltan Mari Journal: Mov Disord Clin Pract Date: 2016-10-01