Mirza Zain Baig1, Alexandra Filkins2, Muhammad Khan3, Muhammad Wasif Saif3, Hassan Aziz4. 1. Department of Surgery, Rudy Ruggles Biomedical Research Institute, Nuvance Health, USA. 2. Department of Surgery, University of Southern California, Keck School of Medicine, CA, USA. 3. Department of Medical Oncology, Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra and Feinstein Institute for Medical Research, USA. 4. Department of Surgery, New York Medical College, Westchester Medical Center Health Network, Valhalla.
Abstract
BACKGROUND: The effects of adjuvant radiation therapy on pancreatic cancer outcomes after resection are not well defined in the literature. METHODS: We abstracted data from the Surveillance, Epidemiology, and End Result (SEER) database to explore the impact of adjuvant radiation on cancer-specific survival in pancreatic cancer patients who received surgical resection. RESULTS: A total of 10,224 patients met our inclusion criteria with 6768 (66.2%) patients treated with surgery only and 3456 (33.8%) treated with surgery plus adjuvant radiation. Surgery followed by adjuvant radiation was associated with significantly improved survival (HR: 0.753, CI: 0.718-0.789, p<0.001). Additionally, female gender and married status were both independently associated with better survival (p<0.05), while advanced age, Caucasian race, higher TNM stage, and higher grade had worse survival outcomes (p<0.05) Asian and Spanish-Hispanic-Latino patients were less likely to receive adjuvant radiotherapy (p<0.05). CONCLUSION: Adjuvant radiation was associated with significantly improved survival after resection for pancreatic cancer. There are significant differences in the patient populations who receive adjuvant radiation.
BACKGROUND: The effects of adjuvant radiation therapy on pancreatic cancer outcomes after resection are not well defined in the literature. METHODS: We abstracted data from the Surveillance, Epidemiology, and End Result (SEER) database to explore the impact of adjuvant radiation on cancer-specific survival in pancreatic cancer patients who received surgical resection. RESULTS: A total of 10,224 patients met our inclusion criteria with 6768 (66.2%) patients treated with surgery only and 3456 (33.8%) treated with surgery plus adjuvant radiation. Surgery followed by adjuvant radiation was associated with significantly improved survival (HR: 0.753, CI: 0.718-0.789, p<0.001). Additionally, female gender and married status were both independently associated with better survival (p<0.05), while advanced age, Caucasian race, higher TNM stage, and higher grade had worse survival outcomes (p<0.05) Asian and Spanish-Hispanic-Latino patients were less likely to receive adjuvant radiotherapy (p<0.05). CONCLUSION: Adjuvant radiation was associated with significantly improved survival after resection for pancreatic cancer. There are significant differences in the patient populations who receive adjuvant radiation.
Authors: Mohamad A Eloubeidi; Renee A Desmond; C Mel Wilcox; Reda J Wilson; Pavan Manchikalapati; Mona M Fouad; Isam Eltoum; Selwyn M Vickers Journal: Am J Surg Date: 2006-09 Impact factor: 2.565
Authors: Krisha J Opfermann; Amy E Wahlquist; Elizabeth Garrett-Mayer; Ravi Shridhar; Leander Cannick; David T Marshall Journal: Am J Clin Oncol Date: 2014-04 Impact factor: 2.339