Literature DB >> 3435445

Effects of the haem precursor 5-aminolaevulinate on tryptophan metabolism and disposition in the rat.

A A Badawy1, C J Morgan, N R Davis.   

Abstract

5-Aminolaevulinate administration to rats inhibits cerebral 5-hydroxytryptamine synthesis by decreasing tryptophan availability to the brain secondarily to activation of hepatic tryptophan pyrrolase. The results show that tryptophan metabolism and disposition can be influenced by changes in liver haem concentration, and are discussed briefly in relation to mood disorders in the hepatic porphyrias.

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Year:  1987        PMID： 3435445      PMCID： PMC1148535          DOI： 10.1042/bj2480293

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

1.  Letter: Factors influencing effect of hydrocortisone on rat brain tryptophan metabolism.

Authors:  A R Green; H F Woods; P G Knott; G Curzon
Journal:  Nature       Date:  1975-05-08       Impact factor: 49.962

2.  Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857

3.  Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain.

Authors:  A Carlsson; M Lindqvist
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-06       Impact factor: 3.000

4.  Tryptophan oxygenase changes following delta-aminolevulinic acid administration in the rat.

Authors:  L Wetterberg; A Yuwiler; E Geller
Journal:  Life Sci       Date:  1969-10-01       Impact factor: 5.037

5.  The role of haem in the regulation of rat liver tryptophan metabolism.

Authors:  M Salter; C I Pogson
Journal:  Biochem J       Date:  1986-11-15       Impact factor: 3.857

6.  Importance of tryptophan pyrrolase and aromatic amino acid decarboxylase in the catabolism of tryptophan.

Authors:  S N Young; D St-Arnaud-McKenzie; T L Sourkes
Journal:  Biochem Pharmacol       Date:  1978-03-01       Impact factor: 5.858

7.  Letter: Tryptophan plus a pyrrolase inhibitor for depression.

Authors:  A A Badawy; M Evans
Journal:  Lancet       Date:  1975-11-01       Impact factor: 79.321

8.  The effect of exogenous -aminolaevulinate on rat liver haem and cytochromes.

Authors:  R Druyan; A Kelly
Journal:  Biochem J       Date:  1972-10       Impact factor: 3.857

9.  The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo(3,4-d)pyrimidine (Allopurinol).

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1973-07       Impact factor: 3.857

10.  The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1973-12       Impact factor: 3.857
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  2 in total

1.  Increased delta aminolevulinic acid and decreased pineal melatonin production. A common event in acute porphyria studies in the rat.

Authors:  H Puy; J C Deybach; A Bogdan; J Callebert; M Baumgartner; P Voisin; Y Nordmann; Y Touitou
Journal:  J Clin Invest       Date:  1996-01-01       Impact factor: 14.808

2.  Evaluation of Metabolic Changes in Acute Intermittent Porphyria Patients by Targeted Metabolomics.

Authors:  Alex Gomez-Gomez; Paula Aguilera; Klaus Langohr; Gregori Casals; Cristina Pavon; Josep Marcos; Jordi To-Figueras; Oscar J Pozo
Journal:  Int J Mol Sci       Date:  2022-03-16       Impact factor: 5.923
  2 in total

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