Literature DB >> 3435443

Absence of direct coenzyme transfer in an A-B dehydrogenase system.

R S Ehrlich1.   

Abstract

Direct transfer of NADPH between two NADP-dependent dehydrogenases, isocitrate dehydrogenase and glutamate dehydrogenase, has been investigated. These enzymes have opposite stereospecificity for hydrogen transfer to the coenzyme. In contrast with the general direct-transfer mechanism postulated for NAD-dependent dehydrogenases [Srivastava & Bernhard (1986) Science 234, 1081-1086], no evidence for direct transfer in either direction was found for these NADP-dependent dehydrogenases.

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Year:  1987        PMID： 3435443      PMCID： PMC1148529          DOI： 10.1042/bj2480269

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Transient kinetics of nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase from bovine heart mitochondria.

Authors:  K Dalziel; N McFerran; B Matthews; C H Reynolds
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

2.  Equilibrium binding of coenzymes and substrates to nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase from bovine heart mitochondria.

Authors:  C H Reynolds; P W Kuchel; K Dalziel
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

3.  Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. II. Effect on catalytic properties and reactivity of amino acid residues.

Authors:  R F Colman
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

4.  On the mechanism of NADP+-linked isocitrate dehydrogenase from heart mitochondria. I. The kinetics of dissociation of NADPH from its enzyme complex.

Authors:  H R Fatania; B Matthews; K Dalziel
Journal:  Proc R Soc Lond B Biol Sci       Date:  1982-02-22

5.  The reaction of 4-iodoacetamidosalicylic acid with TPN-dependent isocitrate dehydrogenase from pig heart.

Authors:  C R Bacon; R A Bednar; R F Colman
Journal:  J Biol Chem       Date:  1981-07-10       Impact factor: 5.157

6.  Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.

Authors:  C M Smith; G W Plaut
Journal:  Eur J Biochem       Date:  1979-06

7.  A new approach for using cofactor dependent enzymes: example of alcohol dehydrogenase.

Authors:  S Sicsic; P Durand; S Langrene; F le Goffic
Journal:  FEBS Lett       Date:  1984-10-29       Impact factor: 4.124

8.  On the mechanism of NADP+-linked isocitrate dehydrogenase from heart mitochondria. II. The transient-state kinetics of the oxidative decarboxylation of isocitrate.

Authors:  H R Fatania; B Matthews; K Dalziel
Journal:  Proc R Soc Lond B Biol Sci       Date:  1982-02-22

9.  The effects of an acetate-sensitive anion binding site on NADPH binding in glutamate dehydrogenase.

Authors:  P Chalabi; S Maniscalco; L E Cohn; H F Fisher
Journal:  Biochim Biophys Acta       Date:  1987-06-17

10.  Transfer of 1,3-diphosphoglycerate between glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase via an enzyme-substrate-enzyme complex.

Authors:  J P Weber; S A Bernhard
Journal:  Biochemistry       Date:  1982-08-17       Impact factor: 3.162
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  1 in total

1.  Metabolite channeling versus free diffusion: reinterpretation of aldolase-catalysed inactivation of glyceraldehyde-3-phosphate dehydrogenase.

Authors:  B G Vértessy; M Vas
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857
  1 in total

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