Boubakari Ibrahimou1, Ning Sun, Syeda Ishra Azim, Muktar H Aliyu, Tomas R Guilarte. 1. Florida International University, Robert Stempel College of Public Health & Social Work, Department of Biostatistics, Miami, Florida (Dr Ibrahimou, Ms Sun); Vanderbilt University Medical Center, Department of Health Policy and Medicine, Nashville, Tennessee (Dr Aliyu); Florida International University, Robert Stempel College of Public Health & Social Work, Department of Environmental Health Sciences, Miami, Florida (Dr Guilarte); University of New South Wales, School of Psychiatry, Faculty of Medicine, Sydney, Australia (Ms Azim).
Abstract
OBJECTIVE: To explore the interaction between chronic bronchitis and blood cadmium on the prevalence of myocardial infarction. METHODS: We used weighted US-NHANES data. Multivariate survey logistic regression was used to examine the associations between myocardial infarction, cadmium concentration and chronic bronchitis. Adjusted odds ratios, 95% confidence intervals were computed. RESULTS: There was a significant interaction (OR=1.33, CI = [1.01, 1.74]) between chronic bronchitis and blood cadmium level on the presence of myocardial infarction. For 1 μg/L increase in cadmium level, people with chronic bronchitis had 1.65 (1.24 × 1.33) times the odds of having myocardial infarction, while those without chronic bronchitis would be only 1.24 times as likely having the outcome (OR = 1.24, CI = [1.05, 1.46]). CONCLUSION: Findings highlights the role of chronic bronchitis on the relationship between blood cadmium concentration and myocardial infarction. Prospective cohort designs are needed to confirm these findings.
OBJECTIVE: To explore the interaction between chronic bronchitis and blood cadmium on the prevalence of myocardial infarction. METHODS: We used weighted US-NHANES data. Multivariate survey logistic regression was used to examine the associations between myocardial infarction, cadmium concentration and chronic bronchitis. Adjusted odds ratios, 95% confidence intervals were computed. RESULTS: There was a significant interaction (OR=1.33, CI = [1.01, 1.74]) between chronic bronchitis and blood cadmium level on the presence of myocardial infarction. For 1 μg/L increase in cadmium level, people with chronic bronchitis had 1.65 (1.24 × 1.33) times the odds of having myocardial infarction, while those without chronic bronchitis would be only 1.24 times as likely having the outcome (OR = 1.24, CI = [1.05, 1.46]). CONCLUSION: Findings highlights the role of chronic bronchitis on the relationship between blood cadmium concentration and myocardial infarction. Prospective cohort designs are needed to confirm these findings.
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