Literature DB >> 3435181

Epidermal cell growth-dependent arylhydrocarbon-hydroxylase (AHH) activity in vitro.

B Thiele1, H F Merk, B Bonnekoh, G Mahrle, G K Steigleder.   

Abstract

Cytochrome P-450-dependent arylhydrocarbon-hydroxylase (AHH) activity and inducibility by benzanthracene (BA) was measured in cultured guinea pig and human epidermal cells. Basal AHH-activity (AHHb) in guinea pig epidermal cells was much higher than in human epidermal cells. AHHb in guinea pig epidermal cells was directly related to the labeling index and decreased to the original level between the 5th and 7th day of cell culturing. On the other hand, the induction-ratio of AHH reached its maximum level when the number of cells began to rise (proliferation phase) and remained high at day 7 of the cell culture. These results suggest a cell growth dependent activity and inducibility of carcinogen-metabolizing enzymes, such as AHH, in isolated epidermal cells.

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Year:  1987        PMID： 3435181     DOI： 10.1007/BF00413283

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  5 in total

1.  Preferential binding of benzo[a]pyrene diol epoxide to the linker DNA of human foreskin fibroblasts in S phase in the presence of benzamide.

Authors:  P Kurian; A M Jeffrey; G E Milo
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  Aryl hydrocarbon hydroxylase, epoxide hydrolase, and benzo[a]-pyrene metabolism in human epidermis: comparative studies in normal subjects and patients with psoriasis.

Authors:  D R Bickers; H Mukhtar; T Dutta-Choudhury; C L Marcelo; J J Voorhees
Journal:  J Invest Dermatol       Date:  1984-07       Impact factor: 8.551

3.  Identifying human cells capable of metabolizing various classes of carcinogens.

Authors:  A E Aust; M R Antczak; V M Maher; J J McCormick
Journal:  J Supramol Struct Cell Biochem       Date:  1981

4.  Inducibility of arylhydrocarbon-hydroxylase activity in human hair follicles by topical application of liquor carbonis detergens (coal tar).

Authors:  H Merk; M Rumpf; K Bolsen; G Wirth; G Goerz
Journal:  Br J Dermatol       Date:  1984-09       Impact factor: 9.302

5.  Studies on microsomal cytochrome P-450, monooxygenases and epoxide hydrolase in cultured keratinocytes and intact epidermis from BALB/C mice.

Authors:  D R Bickers; C L Marcelo; T Dutta-Choudhury; H Mukhtar
Journal:  J Pharmacol Exp Ther       Date:  1982-10       Impact factor: 4.030
  5 in total
  2 in total

Review 1.  Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; Robert Landsiedel
Journal:  Arch Toxicol       Date:  2018-06-18       Impact factor: 5.153

Review 2.  Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; K Guth; R Landsiedel
Journal:  Arch Toxicol       Date:  2014-11-05       Impact factor: 5.153
  2 in total

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