Praneetha Jain1, Azhaar Galiya1, Sharon Luke Philip1, Uday Venkat Mateti1, P S Supriya2, Sai Krishna Gudi3, Shraddha Shetty4. 1. Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Department of Pharmacy Practice, Mangaluru-575018, India. 2. Nitte (Deemed to be University), Justice KS Hegde Charitable Hospital, Department of General Medicine, Mangaluru-575018, India. 3. Rady Faculty of Health Sciences, College of Pharmacy, University of Mannitoba, Canada. 4. Nitte (Deemed to be University), KS Hegde Medical Academy, Department of Biostatistics, Mangaluru, Mangaluru-575018, India.
Abstract
BACKGROUND: As the susceptibility pattern of different pathogens varies among different settings, the evaluation of appropriate clinical diagnosis and timely initiation of the empirical antibiotic treatment based on the local susceptibility data is crucial in the management of sepsis. METHODS: A retrospective study was conducted among adult patients with sepsis at a charitable hospital in Mangaluru. The essential details such as patient demographics, culture specimens, organisms, resistance/susceptibility pattern, laboratory data, empirical therapy, and clinical outcomes were collected from the medical records. Descriptive statistics were used in analysing the data. RESULTS: A total of 425 patients diagnosed with sepsis during the study period were screened to meet the sample size of 373 positive cultures. Among which 367 (91.3%) samples yielded the bacterial isolates, out of which 250 (68.1%) and 117 (31.9%) were gram-negative and gram-positive organisms respectively. The most common gram-negative organisms isolated were K. pneumoniae (19.9%), A. baumannii (19.6%) & E. coli (12.8%); while Coagulase-negative staphylococcus (14.4%) & S aureus (8.4%) were the predominant gram-positive organisms. The isolated pathogens showed a resistance rate of >50% to the most commonly used antibiotics. CONCLUSION: The present study provides information on the prevalence of the most common pathogens and their resistance pattern to different antibiotics, which plays a vital role in the selection and timely initiation of the appropriate empirical antibiotic therapy. This article is protected by copyright. All rights reserved.
BACKGROUND: As the susceptibility pattern of different pathogens varies among different settings, the evaluation of appropriate clinical diagnosis and timely initiation of the empirical antibiotic treatment based on the local susceptibility data is crucial in the management of sepsis. METHODS: A retrospective study was conducted among adult patients with sepsis at a charitable hospital in Mangaluru. The essential details such as patient demographics, culture specimens, organisms, resistance/susceptibility pattern, laboratory data, empirical therapy, and clinical outcomes were collected from the medical records. Descriptive statistics were used in analysing the data. RESULTS: A total of 425 patients diagnosed with sepsis during the study period were screened to meet the sample size of 373 positive cultures. Among which 367 (91.3%) samples yielded the bacterial isolates, out of which 250 (68.1%) and 117 (31.9%) were gram-negative and gram-positive organisms respectively. The most common gram-negative organisms isolated were K. pneumoniae (19.9%), A. baumannii (19.6%) & E. coli (12.8%); while Coagulase-negative staphylococcus (14.4%) & S aureus (8.4%) were the predominant gram-positive organisms. The isolated pathogens showed a resistance rate of >50% to the most commonly used antibiotics. CONCLUSION: The present study provides information on the prevalence of the most common pathogens and their resistance pattern to different antibiotics, which plays a vital role in the selection and timely initiation of the appropriate empirical antibiotic therapy. This article is protected by copyright. All rights reserved.