Literature DB >> 34348897

Effect of BCG vaccination on proinflammatory responses in elderly individuals.

Nathella Pavan Kumar1, Chandrasekaran Padmapriyadarsini2, Anuradha Rajamanickam3, Shrinivasa B Marinaik2, Arul Nancy3, Srinivasan Padmanaban2, Nabila Akbar2, Manoj Murhekar4, Subash Babu5.   

Abstract

We investigated the influence of Bacillus Calmette-Guérin (BCG) vaccination on the unstimulated plasma levels of a wide panel of cytokines, chemokines, acute-phase proteins (APPs), matrix metalloproteinases (MMPs), and growth factors in a group of healthy elderly individuals (age, 60 to 80 years) at baseline (before vaccination) and 1 month after vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrated that BCG vaccination resulted in diminished plasma levels of types 1, 2, and 17 and other proinflammatory cytokines and type 1 interferons. BCG vaccination also resulted in decreased plasma levels of CC, CXC chemokines, APPs, MMPs, and growth factors. Plasma levels of the aforementioned parameters were significantly lower in vaccinated individuals when compared to unvaccinated control individuals. Thus, our study demonstrates the immunomodulatory properties of BCG vaccination and suggests its potential utility in nonspecific vaccination of COVID-19 by down-modulating pathogenic inflammatory responses.
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

Entities:  

Year:  2021        PMID： 34348897     DOI： 10.1126/sciadv.abg7181

Source DB:  PubMed          Journal:  Sci Adv        ISSN： 2375-2548            Impact factor:   14.136


  6 in total

Review 1.  BCG Vaccination: A potential tool against COVID-19 and COVID-19-like Black Swan incidents.

Authors:  Wenping Gong; Yingqing Mao; Yuexi Li; Yong Qi
Journal:  Int Immunopharmacol       Date:  2022-05-17       Impact factor: 5.714

Review 2.  Train the Trainer: Hematopoietic Stem Cell Control of Trained Immunity.

Authors:  Marco De Zuani; Jan Frič
Journal:  Front Immunol       Date:  2022-01-27       Impact factor: 7.561

Review 3.  Fiction and Facts about BCG Imparting Trained Immunity against COVID-19.

Authors:  Gurpreet Kaur; Sanpreet Singh; Sidhanta Nanda; Mohammad Adeel Zafar; Jonaid Ahmad Malik; Mohammad Umar Arshi; Taruna Lamba; Javed Naim Agrewala
Journal:  Vaccines (Basel)       Date:  2022-06-23

4.  Randomized clinical trial of BCG vaccine in patients with convalescent COVID-19: Clinical evolution, adverse events, and humoral immune response.

Authors:  Mehrsa Jalalizadeh; Keini Buosi; Franciele A V Dionato; Luciana S B Dal Col; Cristiane F Giacomelli; Karen L Ferrari; Ana Carolina Pagliarone; Patrícia A F Leme; Cristiane L Maia; Reza Yadollahvandmiandoab; Quoc-Dien Trinh; Kleber G Franchini; Marcio C Bajgelman; Leonardo O Reis
Journal:  J Intern Med       Date:  2022-06-03       Impact factor: 13.068

5.  Cyclic di-AMP as endogenous adjuvant enhanced BCG-induced trained immunity and protection against Mycobacterium tuberculosis in mice.

Authors:  Huanhuan Ning; Jian Kang; Yanzhi Lu; Xuan Liang; Jie Zhou; Rui Ren; Shan Zhou; Yong Zhao; Yanling Xie; Lu Bai; Linna Zhang; Yali Kang; Xiaojing Gao; Mingze Xu; Yanling Ma; Fanglin Zhang; Yinlan Bai
Journal:  Front Immunol       Date:  2022-08-23       Impact factor: 8.786

6.  BCG vaccine safety in COVID-19 convalescent adults: BATTLE a randomized controlled trial.

Authors:  Franciele A V Dionato; Mehrsa Jalalizadeh; Keini Buosi; Marília B Visacri; Luciana S B Dal Col; Cristiane F Giacomelli; Patricia A F Leme; Cristiane L Maia; Patricia Moriel; Leonardo O Reis
Journal:  Vaccine       Date:  2022-06-20       Impact factor: 4.169
  6 in total

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