Sayed-Hamidreza Mozhgani1,2, Farid Rajabi3, Mohsen Qurbani3, Yousef Erfani4, Somayeh Yaslianifard2,5, Azam Moosavi6, Kiomars Pourrostami7, Ali Baradaran Bagheri8, Alireza Soleimani9, Farida Behzadian10, Mahshid Safavi11, Farhad Rezaei3. 1. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. 2. Department of Microbiology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran. 3. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 4. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. 5. Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran. 6. Department of Biochemistry, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran. 7. Department of Pediatrics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. 8. Department of Neurosurgery, Madani Hospital, Alborz University of Medical Sciences, Karaj, Iran. 9. Department of Infectious Disease, Alborz University of Medical Sciences, Karaj, Iran. 10. Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, Tehran, Iran. 11. Student Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Abstract
INTRODUCTION: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021. METHODS: The literature search was based on keywords including "chronic fatigue syndrome and HHV 6," "chronic fatigue syndrome and HHV-6," "chronic fatigue syndrome and HHV6," "chronic fatigue syndrome and Herpes virus 6," and "chronic fatigue syndrome and Herpesvirus6" in MEDLINE (PubMed), Web of Science, and EMBASE. RESULTS: The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger's test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies. DISCUSSION: In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.
INTRODUCTION: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021. METHODS: The literature search was based on keywords including "chronic fatigue syndrome and HHV 6," "chronic fatigue syndrome and HHV-6," "chronic fatigue syndrome and HHV6," "chronic fatigue syndrome and Herpes virus 6," and "chronic fatigue syndrome and Herpesvirus6" in MEDLINE (PubMed), Web of Science, and EMBASE. RESULTS: The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger's test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies. DISCUSSION: In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.
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