| Literature DB >> 34348063 |
Emily Kuhlmann1, Ellen van der Plas2, Eric Axelson2, Amy L Conrad3.
Abstract
The present study evaluated brain development in persons with isolated cleft lip and/or cleft palate (iCL/P) compared to unaffected controls using an accelerated longitudinal design. A sample of 134 males and females, ages 7-27 years, with iCL/P (184 observations, total) was compared to 144 unaffected controls (208 evaluations, total) on Wechsler Index scores and volumetric data from structural MRI scans. Boys with isolated cleft palate had verbal IQ 15.5 points lower than perceptual IQ; a clinically significant difference. Participants with iCL/P had differential growth trajectories of regional cerebrum matter and consistently lower volumes of cerebellar gray matter and subcortical matter.Entities:
Mesh：
Year: 2021 PMID： 34348063 PMCID： PMC8814052 DOI： 10.1080/87565641.2021.1946691
Source DB: PubMed Journal: Dev Neuropsychol ISSN： 1532-6942 Impact factor: 2.113