State-of-the-art Hepatocellular Carcinoma Biomarker Detection by Biosensor Technology-a Review.

Biosensors have become a very interesting field in recent years, thanks to their potential to be converted into self-diagnostic technologies. Being able to analyze a biomarker with different biosensor systems has great potential. This potential is important in terms of time, cost, and practicality with its use in the analysis of difficult-to-diagnose diseases in clinical studies. In this review, the biosensors used in the determination of hepatocellular carcinoma (HCC) biomarkers were compiled. Electrochemical, optical, and piezoelectric biosensors used in the analysis of proteins, DNA, RNA, and cells with varying concentrations in HCC can be designed based on antibodies, nanocomposites, DNA, and aptamers.