Literature DB >> 34344469

Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review.

Yan Zhang1, Chu-Yun Liu1, Wei-Can Chen1, Yan-Chuan Shi2, Cong-Mei Wang1, Shu Lin3,4,5, He-Fan He6.   

Abstract

Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous systems. NPY affects the nutritional and inflammatory microenvironments through its interaction with immune cells, brain-derived trophic factor (BDNF), and angiogenesis promotion to maintain body homeostasis. Additionally, NPY has great potential for therapeutic applications against various diseases, especially as an adjuvant therapy for stem cells. In this review, we discuss the research progress regarding NPY, as well as the current evidence for the regulation of NPY in each microenvironment, and provide prospects for further research on related diseases.
© 2021. The Author(s).

Entities:  

Keywords:  Microenvironments; Neuropeptide Y; Neurotrophic factors

Year:  2021        PMID： 34344469     DOI： 10.1186/s13578-021-00657-7

Source DB:  PubMed          Journal:  Cell Biosci        ISSN： 2045-3701            Impact factor:   7.133


  130 in total

Review 1.  A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans.

Authors:  Min Yi; Hekai Li; Zhiye Wu; Jianyun Yan; Qicai Liu; Caiwen Ou; Minsheng Chen
Journal:  Cell Physiol Biochem       Date:  2017-12-22

2.  Excessive release of endogenous neuropeptide Y into cerebrospinal fluid after treatment of spontaneous subarachnoid haemorrhage and its possible impact on self-reported neuropsychological performance - results of a prospective clinical pilot study on good-grade patients.

Authors:  Elisabeth Bründl; Martin Proescholdt; Petra Schödel; Sylvia Bele; Julius Höhne; Florian Zeman; Eva-Maria Stoerr; Alexander Brawanski; Karl-Michael Schebesch
Journal:  Neurol Res       Date:  2018-09-14       Impact factor: 2.448

3.  Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.

Authors:  D G Morgan; R N Kulkarni; J D Hurley; Z L Wang; R M Wang; M A Ghatei; A E Karlsen; S R Bloom; D M Smith
Journal:  Diabetologia       Date:  1998-12       Impact factor: 10.122

4.  Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability.

Authors:  Lijun Li; Amir H Najafi; Joanna B Kitlinska; Richard Neville; James Laredo; Stephen E Epstein; Mary Susan Burnett; Zofia Zukowska
Journal:  J Cardiovasc Transl Res       Date:  2011-04-06       Impact factor: 4.132

5.  Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow.

Authors:  Min Hee Park; Hee Kyung Jin; Woo-Kie Min; Won Woo Lee; Jeong Eun Lee; Haruhiko Akiyama; Herbert Herzog; Grigori N Enikolopov; Edward H Schuchman; Jae-sung Bae
Journal:  EMBO J       Date:  2015-04-27       Impact factor: 11.598

6.  Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y.

Authors:  W Gil Wier; Wei-Jin Zang; Christine Lamont; Hema Raina
Journal:  Exp Physiol       Date:  2008-10-17       Impact factor: 2.969

7.  Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon.

Authors:  M Goumain; T Voisin; A M Lorinet; M Laburthe
Journal:  Biochem Biophys Res Commun       Date:  1998-06-09       Impact factor: 3.575

Review 8.  Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis.

Authors:  Courtney M Clark; Rosemary M Clark; Joshua A Hoyle; Tracey C Dickson
Journal:  J Neurochem       Date:  2020-08-01       Impact factor: 5.372

Review 9.  NPY regulation of bone remodelling.

Authors:  Nicola J Lee; Herbert Herzog
Journal:  Neuropeptides       Date:  2009-09-11       Impact factor: 3.286

Review 10.  The Role of Neuropeptide Y in Cardiovascular Health and Disease.

Authors:  Cheryl M J Tan; Peregrine Green; Nidi Tapoulal; Adam J Lewandowski; Paul Leeson; Neil Herring
Journal:  Front Physiol       Date:  2018-09-19       Impact factor: 4.566
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  4 in total

Review 1.  Wearable electrochemical biosensors to measure biomarkers with complex blood-to-sweat partition such as proteins and hormones.

Authors:  David Pérez; Jahir Orozco
Journal:  Mikrochim Acta       Date:  2022-03-01       Impact factor: 6.408

Review 2.  Neurotransmitters: Potential Targets in Glioblastoma.

Authors:  Qiqi Huang; Lishi Chen; Jianhao Liang; Qiongzhen Huang; Haitao Sun
Journal:  Cancers (Basel)       Date:  2022-08-17       Impact factor: 6.575

Review 3.  Immunomodulatory Role of Neuropeptides in the Cornea.

Authors:  Sudan Puri; Brendan M Kenyon; Pedram Hamrah
Journal:  Biomedicines       Date:  2022-08-16

Review 4.  Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study.

Authors:  Ruth Naomi; Muhammad Dain Yazid; Hasnah Bahari; Yong Yoke Keong; Retnagowri Rajandram; Hashim Embong; Soo Huat Teoh; Shariff Halim; Fezah Othman
Journal:  Int J Mol Sci       Date:  2022-03-09       Impact factor: 5.923
  4 in total

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