Guy Trudel1,2,3, Samuel Duchesne-Bélanger1,4, Justin Thomas1,4, Gerd Melkus5,6, Greg O Cron5,6, Peder E Z Larson7, Mark Schweitzer8, Adnan Sheikh5,6, Hakim Louati1, Odette Laneuville1,4. 1. Bone and Joint Research Laboratory, Ottawa Hospital Research Institute, Ottawa, ON, Canada. 2. Department of Medicine, Division of Physiatry, University of Ottawa, Ottawa, ON, Canada. 3. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada. 4. Department of Biology, University of Ottawa, Ottawa, ON, Canada. 5. Department of Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada. 6. Department of Radiology, University of Ottawa, Ottawa, ON, Canada. 7. Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA. 8. Department of Radiology, Stony Brook University NY, New York, NY, USA.
Abstract
BACKGROUND: The quantitative assessment of supraspinatus tendons by conventional magnetic resonance is limited by low contrast-to-noise ratio (CNR). Magnetic resonance imaging (MRI) scanners operating at 7 Tesla offer high signal-to noise ratio (SNR), low CNR and high spatial resolution that are well-suited for rapidly relaxing tissues like tendons. Few studies have applied T2 and T2* mapping to musculoskeletal imaging and to the rotator cuff tendons. Our objective was to analyze the T2 and T2* relaxation times from surgically repaired supraspinatus tendons and the effect of bone channeling. METHODS: One supraspinatus tendon of 112 adult female New Zealand white rabbits was surgically detached and repaired one week later. Rabbits were randomly assigned to channeling (n=64) or control (n=48) groups and harvested at 0, 1, 2, and 4 weeks. A 7T magnet was used for signal acquisition. For T2 mapping, a sagittal multi slice 2D multi-echo spin-echo (MESE) CPMG sequence with fat saturation was applied and T2* mapping was performed using a 3D UTE sequence. Magnetic resonance images from supraspinatus tendons were analyzed by two raters. Three regions of interest were manually drawn on the first T2-weighted dataset. For T2 and T2*, different ROI masks were generated to obtain relaxation times. RESULTS: T2-weighted maps but not T2*-weighted maps generated reliable signals for relaxation time measurement. Torn supraspinatus tendons had lower T2 than controls at the time of repair (20.0±3.4 vs. 25.6±3.9 ms; P<0.05). T2 increased at 1, 2 and 4 postoperative weeks: 22.7±3.1, 23.3±3.9 and 24.0±5.1 ms, respectively, and values were significantly different from contralateral supraspinatus tendons (24.8±3.1; 26.8±4.3 and 26.5±3.6 ms; all P<0.05). Bone channeling did not affect T2 (P>0.05). CONCLUSIONS: Supraspinatus tendons detached for 1 week had shorter T2 relaxation time compared to contralateral as measured with 7T MRI. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: The quantitative assessment of supraspinatus tendons by conventional magnetic resonance is limited by low contrast-to-noise ratio (CNR). Magnetic resonance imaging (MRI) scanners operating at 7 Tesla offer high signal-to noise ratio (SNR), low CNR and high spatial resolution that are well-suited for rapidly relaxing tissues like tendons. Few studies have applied T2 and T2* mapping to musculoskeletal imaging and to the rotator cuff tendons. Our objective was to analyze the T2 and T2* relaxation times from surgically repaired supraspinatus tendons and the effect of bone channeling. METHODS: One supraspinatus tendon of 112 adult female New Zealand white rabbits was surgically detached and repaired one week later. Rabbits were randomly assigned to channeling (n=64) or control (n=48) groups and harvested at 0, 1, 2, and 4 weeks. A 7T magnet was used for signal acquisition. For T2 mapping, a sagittal multi slice 2D multi-echo spin-echo (MESE) CPMG sequence with fat saturation was applied and T2* mapping was performed using a 3D UTE sequence. Magnetic resonance images from supraspinatus tendons were analyzed by two raters. Three regions of interest were manually drawn on the first T2-weighted dataset. For T2 and T2*, different ROI masks were generated to obtain relaxation times. RESULTS: T2-weighted maps but not T2*-weighted maps generated reliable signals for relaxation time measurement. Torn supraspinatus tendons had lower T2 than controls at the time of repair (20.0±3.4 vs. 25.6±3.9 ms; P<0.05). T2 increased at 1, 2 and 4 postoperative weeks: 22.7±3.1, 23.3±3.9 and 24.0±5.1 ms, respectively, and values were significantly different from contralateral supraspinatus tendons (24.8±3.1; 26.8±4.3 and 26.5±3.6 ms; all P<0.05). Bone channeling did not affect T2 (P>0.05). CONCLUSIONS: Supraspinatus tendons detached for 1 week had shorter T2 relaxation time compared to contralateral as measured with 7T MRI. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: Konstantin Krepkin; Mary Bruno; José G Raya; Ronald S Adler; Soterios Gyftopoulos Journal: Skeletal Radiol Date: 2016-11-28 Impact factor: 2.199
Authors: Salvatore Frangiamore; Grant J Dornan; Marilee P Horan; Sandeep Mannava; Erik M Fritz; Zaamin B Hussain; Gilbert Moatshe; Jonathan A Godin; Jonas Pogorzelski; Peter J Millett Journal: Am J Sports Med Date: 2020-05-14 Impact factor: 6.202
Authors: Siegfried Trattnig; Stefan Zbýň; Benjamin Schmitt; Klaus Friedrich; Vladimir Juras; Pavol Szomolanyi; Wolfgang Bogner Journal: Eur Radiol Date: 2012-06-12 Impact factor: 5.315
Authors: J S Sher; J P Iannotti; G R Williams; R J Herzog; J B Kneeland; S Lisser; N Patel Journal: J Shoulder Elbow Surg Date: 1998 May-Jun Impact factor: 3.019