Na Wang1, Jia Zhang1, Zhangbin Yu2, Bin Tang1, Lin Zhang3, Yujie Yin4, Zengqin Wang5, Shuangshuang Li6, Shanyu Jiang7, Weiwei Hou8, Yan Gao9, Huaiyan Wang3, Xiaoqing Chen4, Xiaoyi Deng5, Yi Lu6, Lingling Zhu8, Lin Bo9, Shuping Han2. 1. The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China. 2. Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 3. Changzhou Maternity and Child Health Care Hospital, Changzhou, Jiangsu, China. 4. Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China. 5. Xuzhou Maternity and Child Health Care Hospital, Xuzhou, Jiangsu, China. 6. Nantong Maternity and Child Health Care Hospital, Nantong, Jiangsu, China. 7. Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu, China. 8. Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China. 9. Lianyungang Maternity and Child Health Care Hospital, Lianyungang, Jiangsu, China.
Abstract
BACKGROUND: Nutrition status of very preterm infants in the neonatal intensive care unit (NICU) is strongly associated with postnatal growth. This study aimed to develop indicators of nutrition status using growth data of very preterm infants during hospitalization. METHODS: The data of 596 newborns from eight NICUs were retrospectively analyzed. Inclusion criteria were birth at <32 weeks' gestation, NICU admission ≤24 h after delivery, and length of hospital stay ≥28 days. Three indicators were evaluated: (indicator I) prevalence of extrauterine growth restriction (EUGR); (indicator II) z-score for change in weight from birth to discharge, adjusted for birth weight z-score and gestational age; and (indicator III) change in weight z-score from birth to discharge, adjusted for birth weight z-score, gestational age, and time to regain birth weight. Using data from NICU 1 as the reference for the latter two indicators, we established linear regression models of the adjusted change in weight z-score from birth to discharge. The difference between the observed value and the baseline value (calculated by the two models) served as the nutrition indices. RESULTS: The prevalence of EUGR differed significantly between the eight NICUs (P = .009). Statistically significant differences were found between the mean indices calculated by the other two models (all P < .05). CONCLUSIONS: Indicator III, change in weight z-score from birth to discharge (adjusted for birth weight z-score, gestational age, and time to regain birth weight), appears to be the most accurate for evaluating the quality of nutrition in the NICU.
BACKGROUND: Nutrition status of very preterm infants in the neonatal intensive care unit (NICU) is strongly associated with postnatal growth. This study aimed to develop indicators of nutrition status using growth data of very preterm infants during hospitalization. METHODS: The data of 596 newborns from eight NICUs were retrospectively analyzed. Inclusion criteria were birth at <32 weeks' gestation, NICU admission ≤24 h after delivery, and length of hospital stay ≥28 days. Three indicators were evaluated: (indicator I) prevalence of extrauterine growth restriction (EUGR); (indicator II) z-score for change in weight from birth to discharge, adjusted for birth weight z-score and gestational age; and (indicator III) change in weight z-score from birth to discharge, adjusted for birth weight z-score, gestational age, and time to regain birth weight. Using data from NICU 1 as the reference for the latter two indicators, we established linear regression models of the adjusted change in weight z-score from birth to discharge. The difference between the observed value and the baseline value (calculated by the two models) served as the nutrition indices. RESULTS: The prevalence of EUGR differed significantly between the eight NICUs (P = .009). Statistically significant differences were found between the mean indices calculated by the other two models (all P < .05). CONCLUSIONS: Indicator III, change in weight z-score from birth to discharge (adjusted for birth weight z-score, gestational age, and time to regain birth weight), appears to be the most accurate for evaluating the quality of nutrition in the NICU.
Authors: Joohee Lim; So Jin Yoon; Jeong Eun Shin; Jung Ho Han; Soon Min Lee; Ho Seon Eun; Min Soo Park; Kook In Park Journal: J Korean Med Sci Date: 2022-05-23 Impact factor: 5.354