Literature DB >> 34339278

Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.

Marc H Scheetz1,2,3, Gwendolyn M Pais1,2, Thomas P Lodise4, Steven Y C Tong5,6,7, Joshua S Davis7, J Nicholas O'Donnell4, Jiajun Liu8, Michael Neely9, Walter C Prozialeck3, Peter C Lamar3, Nathaniel J Rhodes1,2, Thomas Holland10,11, Sean N Avedissian12,13.   

Abstract

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg·h/liter, respectively.

Entities:  

Keywords:  AKI; CAMERA2; PROVIDE; allometric; biomarkers; glycopeptides; laboratory animals; preclinical; toxicity; vancomycin

Mesh：

Substances：

Year:  2021        PMID： 34339278      PMCID： PMC8448150          DOI： 10.1128/AAC.01060-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats.

Authors:  Nathaniel J Rhodes; Walter C Prozialeck; Thomas P Lodise; Natarajan Venkatesan; J Nicholas O'Donnell; Gwendolyn Pais; Cameron Cluff; Peter C Lamar; Michael N Neely; Anil Gulati; Marc H Scheetz
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Vancomycin Area Under the Curve and Acute Kidney Injury: A Meta-analysis.

Authors:  Doaa M Aljefri; Sean N Avedissian; Nathaniel J Rhodes; Michael J Postelnick; Kevin Nguyen; Marc H Scheetz
Journal:  Clin Infect Dis       Date:  2019-11-13       Impact factor: 9.079

3.  Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model.

Authors:  Gwendolyn M Pais; Jiajun Liu; Sean N Avedissian; Danielle Hiner; Theodoros Xanthos; Athanasios Chalkias; Ernesto d'Aloja; Emanuela Locci; Annette Gilchrist; Walter C Prozialeck; Nathaniel J Rhodes; Thomas P Lodise; Julie C Fitzgerald; Kevin J Downes; Athena F Zuppa; Marc H Scheetz
Journal:  J Antimicrob Chemother       Date:  2020-05-01       Impact factor: 5.790

4.  Prevalence of antimicrobial use in US acute care hospitals, May-September 2011.

Authors:  Shelley S Magill; Jonathan R Edwards; Zintars G Beldavs; Ghinwa Dumyati; Sarah J Janelle; Marion A Kainer; Ruth Lynfield; Joelle Nadle; Melinda M Neuhauser; Susan M Ray; Katherine Richards; Richard Rodriguez; Deborah L Thompson; Scott K Fridkin
Journal:  JAMA       Date:  2014-10-08       Impact factor: 56.272

5.  Benchmarking risk-adjusted adult antibacterial drug use in 70 US academic medical center hospitals.

Authors:  Ron E Polk; Samuel F Hohmann; Sofia Medvedev; Omar Ibrahim
Journal:  Clin Infect Dis       Date:  2011-10-13       Impact factor: 9.079

6.  Estimating National Trends in Inpatient Antibiotic Use Among US Hospitals From 2006 to 2012.

Authors:  James Baggs; Scott K Fridkin; Lori A Pollack; Arjun Srinivasan; John A Jernigan
Journal:  JAMA Intern Med       Date:  2016-11-01       Impact factor: 21.873

7.  Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial.

Authors:  Steven Y C Tong; David C Lye; Dafna Yahav; Archana Sud; J Owen Robinson; Jane Nelson; Sophia Archuleta; Matthew A Roberts; Alan Cass; David L Paterson; Hong Foo; Mical Paul; Stephen D Guy; Adrian R Tramontana; Genevieve B Walls; Stephen McBride; Narin Bak; Niladri Ghosh; Benjamin A Rogers; Anna P Ralph; Jane Davies; Patricia E Ferguson; Ravindra Dotel; Genevieve L McKew; Timothy J Gray; Natasha E Holmes; Simon Smith; Morgyn S Warner; Shirin Kalimuddin; Barnaby E Young; Naomi Runnegar; David N Andresen; Nicholas A Anagnostou; Sandra A Johnson; Mark D Chatfield; Allen C Cheng; Vance G Fowler; Benjamin P Howden; Niamh Meagher; David J Price; Sebastiaan J van Hal; Matthew V N O'Sullivan; Joshua S Davis
Journal:  JAMA       Date:  2020-02-11       Impact factor: 56.272

8.  Indications and Types of Antibiotic Agents Used in 6 Acute Care Hospitals, 2009-2010: A Pragmatic Retrospective Observational Study.

Authors:  Theodoros Kelesidis; Nikolay Braykov; Daniel Z Uslan; Daniel J Morgan; Sumanth Gandra; Birgir Johannsson; Marin L Schweizer; Scott A Weisenberg; Heather Young; Joseph Cantey; Eli Perencevich; Edward Septimus; Arjun Srinivasan; Ramanan Laxminarayan
Journal:  Infect Control Hosp Epidemiol       Date:  2015-10-12       Impact factor: 3.254

9.  Trends in antibacterial use in US academic health centers: 2002 to 2006.

Authors:  Amy L Pakyz; Conan MacDougall; Michael Oinonen; Ronald E Polk
Journal:  Arch Intern Med       Date:  2008-11-10

10.  Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study.

Authors:  Jiajun Liu; Steven Y C Tong; Joshua S Davis; Nathaniel J Rhodes; Marc H Scheetz
Journal:  Open Forum Infect Dis       Date:  2020-11-04       Impact factor: 3.835
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  4 in total

1.  Risk Factors for Nephrotoxicity in Methicillin-Resistant Staphylococcus aureus Bacteraemia: A Post Hoc Analysis of the CAMERA2 Trial.

Authors:  Amy Legg; Niamh Meagher; Sandra A Johnson; Matthew A Roberts; Alan Cass; Marc H Scheetz; Jane Davies; Jason A Roberts; Joshua S Davis; Steven Y C Tong
Journal:  Clin Drug Investig       Date:  2022-10-10       Impact factor: 3.580

2.  Glomerular Function and Urinary Biomarker Changes between Vancomycin and Vancomycin plus Piperacillin-Tazobactam in a Translational Rat Model.

Authors:  Jack Chang; Gwendolyn M Pais; Kimberly Valdez; Sylwia Marianski; Erin F Barreto; Marc H Scheetz
Journal:  Antimicrob Agents Chemother       Date:  2022-01-10       Impact factor: 5.938

3.  Vancomycin Pharmacokinetics in a Pregnancy Rat Model.

Authors:  Sean N Avedissian; Gwendolyn M Pais; Michelle Pham; Jiajun Liu; Jack Chang; Khrystyna Hlukhenka; Walter Prozialeck; Brooke Griffin; Anil Gulati; Medha D Joshi; Ying Mu; Marc H Scheetz
Journal:  Antimicrob Agents Chemother       Date:  2022-04-21       Impact factor: 5.938

4.  Precision dosing of vancomycin: in defence of AUC-guided therapy in children.

Authors:  Mark E Murphy; Sonya Tang Girdwood; Jennifer L Goldman; Marc H Scheetz; Kevin J Downes
Journal:  J Antimicrob Chemother       Date:  2021-09-15       Impact factor: 5.790
  4 in total

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