Literature DB >> 3433915

Protective effectiveness of an endotoxin-depleted pertussis vaccine.

R M Bannatyne1, J Jackowski.   

Abstract

Pertussis vaccine depleted of endotoxin by the polymyxin-Sepharose affinity chromatography method was tested for toxic activity and protective effectiveness in mice. Preparations containing 1000-fold and 1 000 000-fold less endotoxin fulfilled the established experimental criteria for freedom from toxicity. A fourfold concentrate of the former demonstrated a protection rate only 10% less than that of standard, untreated pertussis vaccine.

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Year:  1987        PMID： 3433915     DOI： 10.1016/0264-410x(87)90149-6

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  2 in total

1.  Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells.

Authors:  B P Mahon; M S Ryan; F Griffin; K H Mills
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

2.  Generating high quality libraries for DIA MS with empirically corrected peptide predictions.

Authors:  Brian C Searle; Kristian E Swearingen; Christopher A Barnes; Tobias Schmidt; Siegfried Gessulat; Bernhard Küster; Mathias Wilhelm
Journal:  Nat Commun       Date:  2020-03-25       Impact factor: 14.919
  2 in total

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