Literature DB >> 3433669

The immune response to viral antigens as a determinant of arthritis in caprine arthritis-encephalitis virus infection.

T C McGuire1.   

Abstract

Evidence is reviewed which indicates that CAEV persists in infected goats with variable and restricted expression. Immunosuppression prevents the lesions caused by CAEV. Arthritis is enhanced in CAEV-challenged goats that have been immunized with inactivated CAEV or are persistently infected with CAEV. A large part of the synovial fluid immunoglobulin is antibody against virion surface glycoproteins. These observations support the hypothesis that the immune response to viral antigens is a major determinant of CAEV arthritis.

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Year:  1987        PMID： 3433669     DOI： 10.1016/0165-2427(87)90162-0

Source DB:  PubMed          Journal:  Vet Immunol Immunopathol        ISSN： 0165-2427            Impact factor:   2.046


  3 in total

1.  Augmentation of lymphocyte and macrophage proliferation by caprine arthritis-encephalitis virus contributes to the development of progressive arthritis.

Authors:  K L Banks; M A Jutila; C A Jacobs; F H Michaels
Journal:  Rheumatol Int       Date:  1989       Impact factor: 2.631

2.  Evidence for linkage between the caprine leucocyte antigen (CLA) system and susceptibility to CAE virus-induced arthritis in goats.

Authors:  G Ruff; S Lazary
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

3.  Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis.

Authors:  G Bertoni; M L Zahno; R Zanoni; H R Vogt; E Peterhans; G Ruff; W P Cheevers; P Sonigo; G Pancino
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103
  3 in total

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