María Teresa Sánchez-González1, Oscar Cienfuegos-Jiménez1, Salomón Álvarez-Cuevas2, Antonio Ali Pérez-Maya3, Gissela Borrego-Soto4, Iván Alberto Marino-Martínez1,2. 1. Universidad Autónoma de Nuevo León, Centro de Investigación y Desarrollo en Ciencias de la Salud Monterrey, Nuevo León, México. 2. Universidad Autónoma de Nuevo León, Departamento de Patología, Facultad de Medicina Monterrey, Nuevo León, México. 3. Universidad Autónoma de Nuevo León, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina Monterrey, Nuevo León, México. 4. Department of Molecular Biosciences, University of Texas at Austin Austin, Texas, United States of America.
Abstract
The COVID-19 pandemic has revealed the susceptibility of certain populations to RNA virus infection. This variety of agents is currently the cause of severe respiratory diseases (SARS-CoV2 and Influenza), Hepatitis C, measles and of high prevalence tropical diseases that are detected throughout the year (Dengue and Zika). The rs10774671 polymorphism is a base change from G to A in the last nucleotide of intron-5 of the OAS1 gene. This change modifies a splicing site and generates isoforms of the OAS1 protein with a higher molecular weight and a demonstrated lower enzymatic activity. The low activity of these OAS1 isoforms makes the innate immune response against RNA virus infections less efficient, representing a previously unattended risk factor for certain populations. OBJECTIVE: Determine the distribution of rs10774671 in the open population of Mexico. METHODS: In 98 healthy volunteers, allelic and genotypic frequencies were determined by qPCR using allele specific labeled probes, and the Hardy-Weinberg equilibrium was determined. RESULTS: The A-allele turned out to be the most prevalent in the analyzed population. CONCLUSIONS: Our population is genetically susceptible to RNA virus disease due to the predominant presence of the A allele of rs10774671 in the OAS1 gene. IJMEG
The COVID-19 pandemic has revealed the susceptibility of certain populations to RNA virus infection. This variety of agents is currently the cause of severe respiratory diseases (SARS-CoV2 and Influenza), Hepatitis C, measles and of high prevalence tropical diseases that are detected throughout the year (Dengue and Zika). The rs10774671 polymorphism is a base change from G to A in the last nucleotide of intron-5 of the OAS1 gene. This change modifies a splicing site and generates isoforms of the OAS1 protein with a higher molecular weight and a demonstrated lower enzymatic activity. The low activity of these OAS1 isoforms makes the innate immune response against RNA virus infections less efficient, representing a previously unattended risk factor for certain populations. OBJECTIVE: Determine the distribution of rs10774671 in the open population of Mexico. METHODS: In 98 healthy volunteers, allelic and genotypic frequencies were determined by qPCR using allele specific labeled probes, and the Hardy-Weinberg equilibrium was determined. RESULTS: The A-allele turned out to be the most prevalent in the analyzed population. CONCLUSIONS: Our population is genetically susceptible to RNA virus disease due to the predominant presence of the A allele of rs10774671 in the OAS1 gene. IJMEG
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