Literature DB >> 3433593

Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats.

K Babaya1, S Takahashi, H Momose, H Matsuki, K Sasaki, S Samma, S Ozono, Y Hirao, E Okajima.   

Abstract

Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divided into 26 groups to follow regimens of single chemotherapy. All drugs were administered intraperitoneally except in one group that was treated orally. In our experimental series, 5-fluorouracil (5-FU), N-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), carbazilquinone (CQ), vincristine (VCR) and cis-diamminedichloroplatinum (CDDP) were effective in inhibiting the incidence of bladder tumor, however, adriamycin (ADM), mitomycin C (MMC), neocarsinostatin (NCS), cyclophosphamide (CPM) and bleomycin (BLM) were not effective.

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Year:  1987        PMID： 3433593     DOI： 10.1007/BF00265661

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  21 in total

1.  Effects of sex hormones on development of urinary bladder tumours in rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

Authors:  E Okajima; T Hiramatsu; K Iriya; M Ijuin; S Matsushima
Journal:  Urol Res       Date:  1975-08-08

2.  Use of 5-fluorouracil in treatment of bladder carcinomas.

Authors:  T L DEREN; W L WILSON
Journal:  J Urol       Date:  1960-04       Impact factor: 7.450

3.  Vincristine treatment of advanced cancer: a cooperative study of 392 cases.

Authors:  J F Holland; C Scharlau; S Gailani; M J Krant; K B Olson; J Horton; B I Shnider; J J Lynch; A Owens; P P Carbone; J Colsky; D Grob; S P Miller; T C Hall
Journal:  Cancer Res       Date:  1973-06       Impact factor: 12.701

4.  Effects of foreign bodies on development of urinary bladder tumors in rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine.

Authors:  E Okajima; T Hiramatsu; Y Motomiya; T Kondo; Y Hirao
Journal:  Urol Res       Date:  1973-12

5.  Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide.

Authors:  E Ertürk; S M Cohen; J M Price; G T Bryan
Journal:  Cancer Res       Date:  1969-12       Impact factor: 12.701

6.  Effect of carbazilquinone on transplantable and primary tumors in mice.

Authors:  M Arakawa; H Nakao; T Aoki
Journal:  Gan       Date:  1970-12

7.  Effect of dose on urinary bladder carcinogenesis induced in F344 rats by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

Authors:  M Arai; S M Cohen; J B Jacobs; G H Friedell
Journal:  J Natl Cancer Inst       Date:  1979-04       Impact factor: 13.506

8.  Different susceptibilities of the urinary bladder epithelium of animal species to three nitroso compounds.

Authors:  M Hirose; S Fukushima; M Hananouchi; T Shirai; T Ogiso
Journal:  Gan       Date:  1976-04

9.  Urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in dogs.

Authors:  E Okajima; T Hiramatsu; K Hirao; M Ijuin; Y Hirao; K Babaya; S Ikuma; S Ohara; T Shiomi; T Hijioka; H Ohishi
Journal:  Cancer Res       Date:  1981-05       Impact factor: 12.701

10.  Effect of chemotherapeutic agents on the growth of rat bladder cancer, BC-47.

Authors:  T Iwaguchi; H Kitagawa
Journal:  Gan       Date:  1978-02
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  3 in total

1.  Rat urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine and N-methyl-N-nitrosourea.

Authors:  S Ozono; K Babaya; K Sasaki; S Okamoto; H Momose; K Fujimoto; K Tsumatani; H Yamaguchi; Y Hirao; E Okajima
Journal:  Urol Res       Date:  1990

2.  A prospective randomized study of prophylaxis of tumor recurrence following transurethral resection of superficial bladder cancer--intravesical thio-TEPA versus oral UFT.

Authors:  Y Hirao; E Okajima; S Ozono; S Samma; K Sasaki; T Hiramatsu; K Babaya; S Watanabe; Y Maruyama
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

3.  Suicide gene therapy for chemically induced rat bladder tumor entailing instillation of adenoviral vectors.

Authors:  S Akasaka; S Suzuki; H Shimizu; T Igarashi; M Akimoto; T Shimada
Journal:  Jpn J Cancer Res       Date:  2001-05
  3 in total

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