Jessie N Zurita-Cruz1, Miguel A Villasís-Keever2, Leticia Manuel-Apolinar3, Leticia Damasio-Santana4, Alejandro Gutierrez-Gonzalez5, Guillermo Wakida-Kusunoki6, Michel Padilla-Rojas7, Cesar Maldonado-Rivera8, Eulalia Garrido-Magaña9, Aleida de J Rivera-Hernández10, Elisa Nishimura-Meguro11. 1. Clinical Research Department, Hospital Infantil de México Federico Gómez, and Medicine Faculty of Autonomous National University, Calle Doctor Márquez 162 Col. Doctores, C.P. 06720 Mexico City, Mexico; Unit of Nutrition, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, C.P. 06720 México City, Mexico. Electronic address: zuritajn@hotmail.com. 2. Unit of Analysis and Synthesis of the Evidence, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, C.P. 06720 México City, Mexico. Electronic address: miguel.villasis@gmail.com. 3. Department of Endocrinology Research, Hospital of Medical Specialties, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, CP 06720 México City, Mexico. Electronic address: letymanu@yahoo.com.mx. 4. Department of Endocrinology Research, Hospital of Medical Specialties, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, CP 06720 México City, Mexico. Electronic address: ldamasiosantana@yahoo.com.mx. 5. Computer Research Center of Instituto Politecnico Nacional, Av. Luis Enrique Erro S/N, Unidad Profesional Adolfo López Mateos, Zacatenco, C.P. 07738 Mexico City, Mexico. Electronic address: zottacko@gmail.com. 6. Pediatrics Service, South Central Hospital of High Specialty of Petroleos Mexicanos, Health Services of Petroleos Mexicanos, Anillo Periferico 4091, Col. Fuentes del Pedregal, Tlalpan, C.P. 14140 Mexico City, Mexico. Electronic address: guillewakida@yahoo.com.mx. 7. Pediatrics Service, South Central Hospital of High Specialty of Petroleos Mexicanos, Health Services of Petroleos Mexicanos, Anillo Periferico 4091, Col. Fuentes del Pedregal, Tlalpan, C.P. 14140 Mexico City, Mexico. Electronic address: mitchellmartinpadillarojas@yahoo.com.mx. 8. Pediatrics Service, South Central Hospital of High Specialty of Petroleos Mexicanos, Health Services of Petroleos Mexicanos, Anillo Periferico 4091, Col. Fuentes del Pedregal, Tlalpan, C.P. 14140 Mexico City, Mexico. Electronic address: dr.cesarmaldonado@gmail.com. 9. Department of Pediatric Endocrinology, Children's Hospital, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, C.P. 06720 México City, Mexico. Electronic address: garridolulu@hotmail.com. 10. Department of Pediatric Endocrinology, Children's Hospital, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, C.P. 06720 México City, Mexico. Electronic address: riha0306@yahoo.com.mx. 11. Department of Pediatric Endocrinology, Children's Hospital, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, C.P. 06720 México City, Mexico. Electronic address: erinishimura@prodigy.net.mx.
Abstract
OBJECTIVE: To compare cardiometabolic factors and adipokines between patients with recently diagnosed CPP and controls without CPP, paired by BMI Z scores (BMIz) and classified into girls with adequate nutritional status and girls who are overweight or obese. METHODS: This cross-sectional study was performed from January 2012 to May 2015 at two tertiary care pediatric centers in Mexico City. We included female patients with idiopathic CPP without other chronic pathology and healthy controls. Patients were divided into groups, BMI < 85th and BMI ≥ 85th percentile, according to 2000 CDC Growth Charts. Anthropometric data and fasting plasma concentrations of lipids, glucose, insulin, and leptin were assessed. RESULTS: There were 73 patients with CPP and 82 without CPP. Sixty-six patients were matched between the groups; no significant difference was noted between the groups according to zBMI. However, differences in the bone/chronological age relationship, birth weight and proportions in different Tanner stages were observed. Among girls with normal BMI, the percentage of body fat (24.6% vs 18.9%, p < 0.001), serum triglycerides (102.9 vs 54.3 mg/dl, p < 0.001), leptin (7.46 vs 5.4 ng/ml, p = 0.010) and free leptin (0.44 vs 0.29 ng/ml, p = 0.044) were higher in those with CPP; additionally, girls with CPP presented a higher proportion of hypertriglyceridemia. In the overweight/obese group, adiponectin levels were lower in girls with CPP (6.23 vs 7.28 pg/ml, p = 0.011). CONCLUSIONS: Girls with CPP and normal BMI at diagnosis had a worse cardiometabolic profile, as reflected by higher levels of free leptin, and higher proportion of hypertriglyceridemia than girls without CPP.
OBJECTIVE: To compare cardiometabolic factors and adipokines between patients with recently diagnosed CPP and controls without CPP, paired by BMI Z scores (BMIz) and classified into girls with adequate nutritional status and girls who are overweight or obese. METHODS: This cross-sectional study was performed from January 2012 to May 2015 at two tertiary care pediatric centers in Mexico City. We included female patients with idiopathic CPP without other chronic pathology and healthy controls. Patients were divided into groups, BMI < 85th and BMI ≥ 85th percentile, according to 2000 CDC Growth Charts. Anthropometric data and fasting plasma concentrations of lipids, glucose, insulin, and leptin were assessed. RESULTS: There were 73 patients with CPP and 82 without CPP. Sixty-six patients were matched between the groups; no significant difference was noted between the groups according to zBMI. However, differences in the bone/chronological age relationship, birth weight and proportions in different Tanner stages were observed. Among girls with normal BMI, the percentage of body fat (24.6% vs 18.9%, p < 0.001), serum triglycerides (102.9 vs 54.3 mg/dl, p < 0.001), leptin (7.46 vs 5.4 ng/ml, p = 0.010) and free leptin (0.44 vs 0.29 ng/ml, p = 0.044) were higher in those with CPP; additionally, girls with CPP presented a higher proportion of hypertriglyceridemia. In the overweight/obese group, adiponectin levels were lower in girls with CPP (6.23 vs 7.28 pg/ml, p = 0.011). CONCLUSIONS: Girls with CPP and normal BMI at diagnosis had a worse cardiometabolic profile, as reflected by higher levels of free leptin, and higher proportion of hypertriglyceridemia than girls without CPP.