Ester Illiano1, Francesco Trama1, Felice Crocetto2, Gianluigi Califano2, Achille Aveta2, Gloria Motta3, Antonio Luigi Pastore4, Stefano Brancorsini5, Consuelo Fabi5, Elisabetta Costantini1. 1. Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy. 2. Department of General and Specializes surgery, Renal Transplantation, Nephrology, Intensive Care and Pain Management, University Federico II of Naples, Naples, Italy. 3. Urology Clinic, San Donato, Milan, Italy. 4. Department of Medico-Surgical Sciences and Biotechnologies, Urology Unit Sapienza University of Rome, Faculty of Pharmacy and Medicine, Rome, Italy. 5. Department of Experimental Medicine-Section of Terni, University of Perugia, Terni, Italy.
Abstract
INTRODUCTION: The aim of this study was to assess whether antibiotic prophylaxis or therapy is sufficient for laparoscopic or vaginal prolapse surgery with mesh. METHODS: This is a single-center prospective study. The study was divided into 3 groups. Protocol A: metronidazole (15 mg/kg) and piperacillin-tazobactam (2 g) 1 h before surgery and, for postoperative treatment, gentamycin (160 mg) 1 h before surgery in a single dose. Metronidazole and piperacillin-tazobactam were administered until hospital discharge. Protocol B: gentamycin and piperacillin-tazobactam in the same manner as group A. Protocol C: clindamycin (600 mg) and gentamicin (160 mg) 1 h before surgery in a single dose. RESULTS: We included 87 consecutive patients who underwent prolapse surgery involving mesh prostheses: 57 by the laparoscopic approach and 30 by the vaginal route. Of these, 30 patients were included in protocol A, 30 in protocol B, and 27 in protocol C. There were no statistically significant differences among the 3 protocols regarding any postoperative complications, except for urinary tract infections that were more in the vaginal approach than in the laparoscopic route, in protocol A (p = 0.002). CONCLUSIONS: One-shot prophylaxis can be successfully used in prolapse surgery regardless of the surgical approach.
INTRODUCTION: The aim of this study was to assess whether antibiotic prophylaxis or therapy is sufficient for laparoscopic or vaginal prolapse surgery with mesh. METHODS: This is a single-center prospective study. The study was divided into 3 groups. Protocol A: metronidazole (15 mg/kg) and piperacillin-tazobactam (2 g) 1 h before surgery and, for postoperative treatment, gentamycin (160 mg) 1 h before surgery in a single dose. Metronidazole and piperacillin-tazobactam were administered until hospital discharge. Protocol B: gentamycin and piperacillin-tazobactam in the same manner as group A. Protocol C: clindamycin (600 mg) and gentamicin (160 mg) 1 h before surgery in a single dose. RESULTS: We included 87 consecutive patients who underwent prolapse surgery involving mesh prostheses: 57 by the laparoscopic approach and 30 by the vaginal route. Of these, 30 patients were included in protocol A, 30 in protocol B, and 27 in protocol C. There were no statistically significant differences among the 3 protocols regarding any postoperative complications, except for urinary tract infections that were more in the vaginal approach than in the laparoscopic route, in protocol A (p = 0.002). CONCLUSIONS: One-shot prophylaxis can be successfully used in prolapse surgery regardless of the surgical approach.
Authors: Marine Lallemant; A T M Grob; M Puyraveau; M A G Perik; A H H Alhafidh; M Cosson; R Ramanah Journal: Sci Rep Date: 2022-09-29 Impact factor: 4.996