| Literature DB >> 34329585 |
Stephen L Shiao1, Kathleen M Kershaw2, Jose J Limon3, Sungyong You4, Junhee Yoon4, Emily Y Ko5, Jlenia Guarnerio5, Alka A Potdar3, Dermot P B McGovern3, Shikha Bose6, Tahir B Dar5, Paul Noe5, Jung Lee5, Yuzu Kubota5, Viviana I Maymi5, Madison J Davis5, Regina M Henson5, Rachel Y Choi5, Wensha Yang5, Jie Tang7, Matthew Gargus3, Alexander D Prince3, Zachary S Zumsteg5, David M Underhill8.
Abstract
Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on radiation therapy is not as well understood, and the microbiome comprises more than bacteria. Here, we find that intestinal fungi regulate antitumor immune responses following radiation in mouse models of breast cancer and melanoma and that fungi and bacteria have opposite influences on these responses. Antibiotic-mediated depletion or gnotobiotic exclusion of fungi enhances responsiveness to radiation, whereas antibiotic-mediated depletion of bacteria reduces responsiveness and is associated with overgrowth of commensal fungi. Further, elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in patients with breast cancer and is required for the effects of commensal fungi in mouse models of radiation therapy.Entities:
Keywords: T cells; bacteria; dectin-1; fungi; immunotherapy; macrophages; microbiome; mycobiome; radiation; tumor immunology
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Year: 2021 PMID： 34329585 PMCID： PMC8830498 DOI： 10.1016/j.ccell.2021.07.002
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 38.585