Literature DB >> 343250

Endorphins: naloxone fails to alter experimental pain or mood in humans.

P Grevert, A Goldstein.   

Abstract

In 30 human subjects, experimental pain was produced by either ischemia or cold-water immersion. In a double-blind procedure, intravenous doses of up to 10 milligrams of naloxone hydrochloride in saline were indistinguishable from similarly administered saline alone. There were no effects on subjective pain ratings, finger plethysmograph recordings, or responses to mood-state questionnaires. These laboratory procedures do not activate any functionally significant pain-attenuating or mood-altering effect of endorphins.

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Year:  1978        PMID： 343250     DOI： 10.1126/science.343250

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  Aversive property of opioid receptor blockade in drug-naive mice.

Authors:  R F Mucha; M J Walker
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Regulation of spinal dynorphin 1-17 release by endogenous pituitary adenylyl cyclase-activating polypeptide in the male rat: relevance of excitation via disinhibition.

Authors:  Nai-Jiang Liu; Stephen A Schnell; Stefan Schulz; Martin W Wessendorf; Alan R Gintzler
Journal:  J Pharmacol Exp Ther       Date:  2010-10-25       Impact factor: 4.030

3.  Serotoninergic mechanisms of beta-endorphin-induced hypothermia in rats.

Authors:  M T Lin; Y F Chern; F F Chen; C Y Su
Journal:  Pflugers Arch       Date:  1979-10       Impact factor: 3.657

4.  Endogenous monoamine analgesic systems: amitriptyline in painful diabetic neuropathy.

Authors:  M B Max
Journal:  Anesth Prog       Date:  1987-07

5.  Psychological coping with acute pain: an examination of the role of endogenous opioid mechanisms.

Authors:  S Bruehl; C R Carlson; J F Wilson; J A Norton; G Colclough; M J Brady; J J Sherman; J A McCubbin
Journal:  J Behav Med       Date:  1996-04

6.  Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation.

Authors:  J A Trafton; C Abbadie; K Marek; A I Basbaum
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

7.  Nociceptive flexion reflex and pain rating responses during endogenous opiate blockade with naltrexone in healthy young adults.

Authors:  Christopher R France; Mustafa al'Absi; Christopher Ring; Janis L France; Angie Harju; Lorentz E Wittmers
Journal:  Biol Psychol       Date:  2006-12-27       Impact factor: 3.251

8.  Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization.

Authors:  W Chen; J C G Marvizón
Journal:  Neuroscience       Date:  2009-03-17       Impact factor: 3.590

9.  The effect of opioid receptor blockade on the neural processing of thermal stimuli.

Authors:  Eszter D Schoell; Ulrike Bingel; Falk Eippert; Juliana Yacubian; Kerrin Christiansen; Hilke Andresen; Arne May; Christian Buechel
Journal:  PLoS One       Date:  2010-08-27       Impact factor: 3.240

10.  Naloxone fails to reverse hypnotic alleviation of chronic pain.

Authors:  D Spiegel; L H Albert
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
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