Literature DB >> 3432265

The regulation of expression of human beta-globin genes.

F Grosveld1, M Antoniou, G B van Assendelft, E de Boer, J Hurst, G Kollias, F MacFarlane, N Wrighton.   

Abstract

We have analyzed the regulation of expression of the human beta-globin gene by DNA mediated gene transfer in MEL cells and microinjection in fertilized mouse eggs. The results show that the beta-globin gene contains two regulatory elements: one element in the promoter, that is required for full transcriptional activity and, secondly, a tissue and developmental specific enhancer 3' to the gene.

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Year:  1987        PMID： 3432265

Source DB:  PubMed          Journal:  Prog Clin Biol Res        ISSN： 0361-7742


  4 in total

1.  High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.

Authors:  Suzan Imren; Mary E Fabry; Karen A Westerman; Robert Pawliuk; Patrick Tang; Patricia M Rosten; Ronald L Nagel; Philippe Leboulch; Connie J Eaves; R Keith Humphries
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

2.  Dissecting a locus control region: facilitation of enhancer function by extended enhancer-flanking sequences.

Authors:  B J Aronow; C A Ebert; M T Valerius; S S Potter; D A Wiginton; D P Witte; J J Hutton
Journal:  Mol Cell Biol       Date:  1995-02       Impact factor: 4.272

3.  Systematic targeted integration to study Albumin gene control elements.

Authors:  Sanchari Bhattacharyya; Jianmin Tian; Eric E Bouhassira; Joseph Locker
Journal:  PLoS One       Date:  2011-08-12       Impact factor: 3.240

4.  5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.

Authors:  Ping Kei Chan; Albert Wai; Sjaak Philipsen; Kian-Cheng Tan-Un
Journal:  PLoS One       Date:  2008-05-07       Impact factor: 3.240
  4 in total

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