| Literature DB >> 34321197 |
Han Luo1, Xuyang Xia2, Gyeong Dae Kim3, Yang Liu1, Zhinan Xue2, Lingyun Zhang1, Yang Shu2,4, Tian Yang5, Yan Chen2, Shouyue Zhang2, Haining Chen4, Weihan Zhang4, Ruicen Li6, Huairong Tang6, Birong Dong7, Xianghui Fu2, Wei Cheng2, Wei Zhang8, Li Yang2, Yong Peng2, Lunzhi Dai2, Hongbo Hu2, Yong Jiang5, Changyang Gong2, Yiguo Hu1,2, Jingqiang Zhu1, Zhihui Li1, Carlos Caulin9, Tao Wei10, Jihwan Park11, Heng Xu12,13.
Abstract
Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Moreover, a potential functional role of CREB3L1 on ATC development was revealed by integrated analyses of copy number alteration and transcriptional regulatory network. Multiple genes in differentiation-related pathways (e.g., EMT) were involved as the downstream targets of CREB3L1, increased expression of which can thus predict higher relapse risk of PTC. Collectively, our study provided insights into the heterogeneity and molecular evolution of thyroid cancer and highlighted the potential driver role of CREB3L1 in its dedifferentiation process.Entities:
Year: 2021 PMID： 34321197 DOI： 10.1126/sciadv.abf3657
Source DB: PubMed Journal: Sci Adv ISSN： 2375-2548 Impact factor: 14.136