Michele Mercurio1, Davide Castioni2, Elvira Porco1, Filippo Familiari1, Giorgio Gasparini1, Olimpio Galasso1. 1. Department of Orthopaedic and Trauma Surgery, "Magna Græcia" University, "Mater Domini" University Hospital, V.le Europa, loc. Germaneto, 88100, Catanzaro, Italy. 2. Department of Orthopaedic and Trauma Surgery, "Magna Græcia" University, "Mater Domini" University Hospital, V.le Europa, loc. Germaneto, 88100, Catanzaro, Italy. Electronic address: davide.n.castioni@gmail.com.
Abstract
BACKGROUND: This systematic review investigated the outcomes of revision surgery after periprosthetic ankle infection (PAI). METHODS: According to the PRISMA statement, 9 studies with 131 PAIs surgically treated and analyzed were included. Demographics and surgical techniques with eradication rates and complications were reported. RESULTS: Methicillin-sensitive Staphylococcus aureus (MSSA) (30.4%) and coagulase-negative Staphylococcus (CNS) (26.5%) were the most common microorganisms. The eradication rate was 91.7% with permanent antibiotic spacers (SPC), 84.4% with 2-stage, 79.4% with arthrodesis (AA), and 58.8% with debridement and implant retention (DAIR). DAIR showed a significantly lower eradication rate than 2-stage (p = 0.016) and SPC (p = 0.043). Amputations occurred in 25% of patients after SPC, 8.8% after AA and 3.9% after DAIR. SPC showed a significantly higher amputation rate than DAIR and 2-stage (p = 0.044, and p = 0.017, respectively). CONCLUSIONS: SPC and 2-stage revision show the highest eradication rates, but 2-stage has a lower risk of amputation.
BACKGROUND: This systematic review investigated the outcomes of revision surgery after periprosthetic ankle infection (PAI). METHODS: According to the PRISMA statement, 9 studies with 131 PAIs surgically treated and analyzed were included. Demographics and surgical techniques with eradication rates and complications were reported. RESULTS: Methicillin-sensitive Staphylococcus aureus (MSSA) (30.4%) and coagulase-negative Staphylococcus (CNS) (26.5%) were the most common microorganisms. The eradication rate was 91.7% with permanent antibiotic spacers (SPC), 84.4% with 2-stage, 79.4% with arthrodesis (AA), and 58.8% with debridement and implant retention (DAIR). DAIR showed a significantly lower eradication rate than 2-stage (p = 0.016) and SPC (p = 0.043). Amputations occurred in 25% of patients after SPC, 8.8% after AA and 3.9% after DAIR. SPC showed a significantly higher amputation rate than DAIR and 2-stage (p = 0.044, and p = 0.017, respectively). CONCLUSIONS: SPC and 2-stage revision show the highest eradication rates, but 2-stage has a lower risk of amputation.