Xiao Wei Tan1, Eng Sing Lee2, Matthias Paul Han Sim Toh3, Alvin Wai Mun Lum4, Darren Ee Jin Seah5, Khai Pang Leong6, Christopher Yi Wen Chan7, Daniel Shuen Sheng Fung8, Phern Chern Tor9. 1. Department of Mood Disorder and Anxiety, Institute of Mental Health, 539747, Singapore. Electronic address: xiaowei_tan@imh.com.sg. 2. Clinical Research Unit, National Healthcare Group Polyclinics, 138543, Singapore; Lee Kong Chian School of Medicine, Nanyang Technology University of Singapore, 308232, Singapore. 3. National Public Health & Epidemiology Unit, National Centre for Infectious Diseases, 308442, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, 539747, Singapore. 4. Medical Care Service, Institute of Mental Health, 539747, Singapore. 5. Clinical Research Unit, National Healthcare Group Polyclinics, 138543, Singapore. 6. Tan Tock Seng Hospital, Clinical Research Office, Singapore. 7. Department of Mood Disorder and Anxiety, Institute of Mental Health, 539747, Singapore. 8. Lee Kong Chian School of Medicine, Nanyang Technology University of Singapore, 308232, Singapore; Department of Child Psychiatry, Institute of Mental Health, Singapore, 539747. 9. Department of Mood Disorder and Anxiety, Institute of Mental Health, 539747, Singapore; Lee Kong Chian School of Medicine, Nanyang Technology University of Singapore, 308232, Singapore; Duke-NUS Graduate Medical School, Singapore, 169857.
Abstract
AIM: To compare the risk of death, the prevalence of comorbid chronic physical illness and mortality among an Asian population of patients with mental disorders. METHODS: This was a retrospective data analysing of medical records of patients with schizophrenia, depression, anxiety, bipolar disorder, alcohol use disorder (AUD) or substance use disorder and the comorbid chronic physical illnesses. The hazard risk of death was calculated with Cox regression and compared between patients with and without comorbid chronic physical illness(es). Odds ratios of specific comorbid chronic physical illness were calculated with logistic regression and mean crude death rate was calculated for patients with different mental disorders. RESULTS: A total of 56,447 patients with mental disorders were included in the analysis. Compared to patients without comorbid physical illness, patients with mental-physical comorbidity were associated with a higher risk of death [2.36 (2.22-2.52); hazard ratio (95% CI)] and less estimated survival days [2157 (2142-2172) vs 2508 (2504-2513)]. Compared to other mental disorders, those with AUD had the highest prevalence of two or more comorbid chronic physical illnesses and associated with the highest odds of comorbid hypertension, diabetes mellitus, stroke, nephritis, chronic kidney disease, and cancer. The highest one-year crude death rate was similarly observed in patients with AUD. CONCLUSIONS: Mental-physical comorbidity was associated with a higher risk of death compared to patients with mental disorders only. The highest prevalence of mental-physical comorbidity and mortality were observed in patients with AUD. More attention and resources may be needed to tackle the burden of AUD.
AIM: To compare the risk of death, the prevalence of comorbid chronic physical illness and mortality among an Asian population of patients with mental disorders. METHODS: This was a retrospective data analysing of medical records of patients with schizophrenia, depression, anxiety, bipolar disorder, alcohol use disorder (AUD) or substance use disorder and the comorbid chronic physical illnesses. The hazard risk of death was calculated with Cox regression and compared between patients with and without comorbid chronic physical illness(es). Odds ratios of specific comorbid chronic physical illness were calculated with logistic regression and mean crude death rate was calculated for patients with different mental disorders. RESULTS: A total of 56,447 patients with mental disorders were included in the analysis. Compared to patients without comorbid physical illness, patients with mental-physical comorbidity were associated with a higher risk of death [2.36 (2.22-2.52); hazard ratio (95% CI)] and less estimated survival days [2157 (2142-2172) vs 2508 (2504-2513)]. Compared to other mental disorders, those with AUD had the highest prevalence of two or more comorbid chronic physical illnesses and associated with the highest odds of comorbid hypertension, diabetes mellitus, stroke, nephritis, chronic kidney disease, and cancer. The highest one-year crude death rate was similarly observed in patients with AUD. CONCLUSIONS: Mental-physical comorbidity was associated with a higher risk of death compared to patients with mental disorders only. The highest prevalence of mental-physical comorbidity and mortality were observed in patients with AUD. More attention and resources may be needed to tackle the burden of AUD.
Authors: Sujin Son; Yun Jin Kim; Seok Hyeon Kim; Johanna Inhyang Kim; Sojung Kim; Sungwon Roh Journal: Int J Environ Res Public Health Date: 2022-08-13 Impact factor: 4.614
Authors: Sara Guillen-Aguinaga; Antonio Brugos-Larumbe; Laura Guillen-Aguinaga; Felipe Ortuño; Francisco Guillen-Grima; Luis Forga; Ines Aguinaga-Ontoso Journal: J Cardiovasc Dev Dis Date: 2022-01-13