Commentary: Patch repair for aortomitral endocarditis: Playing the short game or the long game?

Sameer A. Hirji, MD, MPH (left), and Tsuyoshi Kaneko, MD (right)

Combined autologous pericardium aortic valve neocuspidization and transaortic mitral valve repair may be an attractive short-term strategy for aortomitral endocarditis, but long-term durability remains to be determined.

See Article page 101.

Aortomitral infectious endocarditis (IE) remains a challenging problem in cardiac surgery from both technical and management standpoints. Because there are no standardized approaches to the definitive management of aortomitral IE, most procedures often entail nuanced approaches to reconstruction, depending on the extent of IE involvement.

That said, we read with great interest the case report by Benedetto and colleagues in this issue of the Journal. The authors demonstrate a unique concomitant use of the Ozaki procedure for the management of aortic valve IE and transaortic approach to mitral valve repair (MVr) using the autologous pericardium for management of anterior mitral valve leaflet perforation. They are to be congratulated for their outcomes and their innovative approach in a relatively low-risk (EuroScore II, 2.4%), healthy, 50-year-old male.

This case highlights several key advantages. First, Ozaki's autologous pericardium aortic valve neo-cuspidization (AVNeo) procedure helped avoid aortic root replacement using homografts. This alternative approach helps minimize extensive surgical trauma and the inherent risks associated with bleeding in the setting of IE-induced coagulopathy., The use of an aortic valve replacement with biosprosthesis would have been a comparable alternative, but the incidence rate of IE necessitating reoperation is much higher compared with the Ozaki procedure (∼1.0% vs 0.3% per patient-year)., The use of fresh autologous pericardium for MVr further reduced the potential future risk of reinfection due to the presence of prosthetic material. Second, this case avoided the conventional approach to MVr via the left atriotomy. Although the exact benefits of this strategy remain unknown, in theory, avoidance of left atriotomy may further minimize the need for additional incisions. Instead, the transaortic approach facilitated convenient exposure of the anterior mitral valve leaflet for reconstruction through the single exposure via the aorta.

Although the utility of the combined AVNeo procedure and transaortic MVr may represent an attractive short-term strategy and is appropriately justified, there are key long-term issues to consider. First, knowledge of the longevity and subsequent risk of reinfection following this combined procedure is limited, given that the longest reported series with the Ozaki procedure has a 10-year follow-up, with cumulative incidences of reoperation and recurrent aortic regurgitation of 4.2% and 7.3%, respectively. Second, the feasibility of future valve-in-valve transcatheter aortic valve options may be questionable with autologous patching, although the exact feasibility is not known at this time. Finally, the high mitral regurgitation recurrence rate with autologous patching in the absence of annular ring is another concern. Thus, as the durability of this combined approach remains to be determined, we suspect that this patient will most likely require a subsequent future reoperation, given his young age.

Because the long-term performance of the Ozaki procedure in terms of hemodynamics and ease of subsequent valve implantation is not well elucidated, long-term follow-up studies are warranted before this technique becomes routine practice. This begs the question as to whether we are playing the short game or the long game when it comes to dealing with aortomitral endocarditis.